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@ARTICLE{Walzik:307525,
      author       = {D. Walzik and N. Joisten and A. J. Metcalfe and S.
                      Proschinger and A. Schenk and C. Wenzel and A. Henneberg$^*$
                      and M. Schneider$^*$ and S. Calderazzo$^*$ and A. Groll and
                      C. Watzl and C. Opitz$^*$ and D. Helm$^*$ and P. Zimmer},
      title        = {{A}cute exercise rewires the proteomic landscape of human
                      immune cells.},
      journal      = {Nature Communications},
      volume       = {17},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2026-00030},
      pages        = {130},
      year         = {2026},
      note         = {#DKTKZFB26# / 2026 Jan 2;17(1):130},
      abstract     = {The positive effect of exercise on the immune system is
                      widely acknowledged, but the molecular response of immune
                      cells to exercise remains largely unknown. Here, we perform
                      mass-spectrometry-based proteomic analysis on peripheral
                      blood mononuclear cells (PBMC) at a depth of >6000 proteins.
                      Comparing high-intensity interval exercise (HIIE) and
                      moderate-intensity continuous exercise (MICE), matched for
                      time and workload, we identify versatile changes in the
                      proteomic makeup of PBMCs and reveal profound alterations,
                      related to effector function and immune cell activation
                      pathways within one hour following exercise. These changes
                      are more pronounced after HIIE compared to MICE and occur
                      despite identical immune cell mobilization patterns between
                      the two exercise conditions. We further identify an
                      immunoproteomic signature that effectively predicts
                      cardiorespiratory fitness, thus allowing insights into
                      potential exercise-triggered adaptations and immunological
                      health benefits that are mediated by exercise. This study
                      provides a reliable data resource that expands our knowledge
                      on how exercise modulates the immune system, and delivers
                      biological evidence supporting the WHO 2020 guidelines,
                      which highlight exercise intensity as a relevant factor to
                      maintain health.},
      cin          = {B350 / HD01 / W120 / C060},
      ddc          = {500},
      cid          = {I:(DE-He78)B350-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)W120-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {319H - Addenda (POF4-319H)},
      pid          = {G:(DE-HGF)POF4-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41484100},
      doi          = {10.1038/s41467-025-68101-9},
      url          = {https://inrepo02.dkfz.de/record/307525},
}