%0 Journal Article
%A Vavallo, Marica
%A Butt, Julia
%A Cingolani, Sophia
%A Cozza, Giulio
%A Schiavone, Francesco Paolo
%A Dilaghi, Emanuele
%A Belloni, Laura
%A Franchitto, Matteo
%A Annibale, Bruno
%A Waterboer, Tim
%A Lahner, Edith
%T Helicobacter pylori multiplex serology in patients with autoimmune atrophic gastritis negative for Helicobacter pylori at histology: A case-control study.
%J Digestive and liver disease
%V 58
%N 2
%@ 1590-8658
%C [Erscheinungsort nicht ermittelbar]
%I Saunders
%M DKFZ-2026-00031
%P 212-219
%D 2026
%Z 2026 Feb;58(2):212-219
%X Autoimmune atrophic gastritis (AAG) is an immune-mediated disorder affecting the gastric oxyntic mucosa. Two pathogenetic models are proposed: a pure autoimmune disorder or gastric autoimmunity triggered by Helicobacter pylori (Hp)-infection. In AAG, histological diagnosis of Hp may be challenging and serology can help assess exposure to Hp-infection. This study aimed to determine seroreactivity to Hp-antigens in AAG patients by using Hp-multiplex serology assay.A single-centre case-control study on 178 adults: 75 patients with serological and histological AAG diagnosis, 25 controls with histologically Hp-positive-non-atrophic gastritis (Ctr-NAG-Hp+) and 78 subjects with a healthy stomach (Ctr-HS). Sera were analysed using Hp-multiplex serology assay allowing simultaneous detection of antibodies to 13 Hp-proteins. Overall positivity cutoff: seroreactivity to more than 3 Hp-antigens.The number of seroreactive Hp-antigens was higher in AAG than in Ctr-HS(mean±SEM 2.2±0.3 vs 1.4±0.22,p=0.02) and lower than in Ctr-NAG-Hp+ patients (mean±SEM 5.4±0.5,p<0.001).Overall Hp-seropositivity in AAG was two-fold higher than in Ctr-HS but not statistically significant (21.1
%K Atrophic gastritis (Other)
%K Autoimmune gastritis (Other)
%K Helicobacter pylori (Other)
%K Multiplex serology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41484031
%R 10.1016/j.dld.2025.12.002
%U https://inrepo02.dkfz.de/record/307526