TY  - JOUR
AU  - Vavallo, Marica
AU  - Butt, Julia
AU  - Cingolani, Sophia
AU  - Cozza, Giulio
AU  - Schiavone, Francesco Paolo
AU  - Dilaghi, Emanuele
AU  - Belloni, Laura
AU  - Franchitto, Matteo
AU  - Annibale, Bruno
AU  - Waterboer, Tim
AU  - Lahner, Edith
TI  - Helicobacter pylori multiplex serology in patients with autoimmune atrophic gastritis negative for Helicobacter pylori at histology: A case-control study.
JO  - Digestive and liver disease
VL  - 58
IS  - 2
SN  - 1590-8658
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Saunders
M1  - DKFZ-2026-00031
SP  - 212-219
PY  - 2026
N1  - 2026 Feb;58(2):212-219
AB  - Autoimmune atrophic gastritis (AAG) is an immune-mediated disorder affecting the gastric oxyntic mucosa. Two pathogenetic models are proposed: a pure autoimmune disorder or gastric autoimmunity triggered by Helicobacter pylori (Hp)-infection. In AAG, histological diagnosis of Hp may be challenging and serology can help assess exposure to Hp-infection. This study aimed to determine seroreactivity to Hp-antigens in AAG patients by using Hp-multiplex serology assay.A single-centre case-control study on 178 adults: 75 patients with serological and histological AAG diagnosis, 25 controls with histologically Hp-positive-non-atrophic gastritis (Ctr-NAG-Hp+) and 78 subjects with a healthy stomach (Ctr-HS). Sera were analysed using Hp-multiplex serology assay allowing simultaneous detection of antibodies to 13 Hp-proteins. Overall positivity cutoff: seroreactivity to more than 3 Hp-antigens.The number of seroreactive Hp-antigens was higher in AAG than in Ctr-HS(mean±SEM 2.2±0.3 vs 1.4±0.22,p=0.02) and lower than in Ctr-NAG-Hp+ patients (mean±SEM 5.4±0.5,p<0.001).Overall Hp-seropositivity in AAG was two-fold higher than in Ctr-HS but not statistically significant (21.1
KW  - Atrophic gastritis (Other)
KW  - Autoimmune gastritis (Other)
KW  - Helicobacter pylori (Other)
KW  - Multiplex serology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41484031
DO  - DOI:10.1016/j.dld.2025.12.002
UR  - https://inrepo02.dkfz.de/record/307526
ER  -