% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Vavallo:307526,
      author       = {M. Vavallo and J. Butt$^*$ and S. Cingolani and G. Cozza
                      and F. P. Schiavone and E. Dilaghi and L. Belloni and M.
                      Franchitto and B. Annibale and T. Waterboer$^*$ and E.
                      Lahner},
      title        = {{H}elicobacter pylori multiplex serology in patients with
                      autoimmune atrophic gastritis negative for {H}elicobacter
                      pylori at histology: {A} case-control study.},
      journal      = {Digestive and liver disease},
      volume       = {58},
      number       = {2},
      issn         = {1590-8658},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2026-00031},
      pages        = {212-219},
      year         = {2026},
      note         = {2026 Feb;58(2):212-219},
      abstract     = {Autoimmune atrophic gastritis (AAG) is an immune-mediated
                      disorder affecting the gastric oxyntic mucosa. Two
                      pathogenetic models are proposed: a pure autoimmune disorder
                      or gastric autoimmunity triggered by Helicobacter pylori
                      (Hp)-infection. In AAG, histological diagnosis of Hp may be
                      challenging and serology can help assess exposure to
                      Hp-infection. This study aimed to determine seroreactivity
                      to Hp-antigens in AAG patients by using Hp-multiplex
                      serology assay.A single-centre case-control study on 178
                      adults: 75 patients with serological and histological AAG
                      diagnosis, 25 controls with histologically
                      Hp-positive-non-atrophic gastritis (Ctr-NAG-Hp+) and 78
                      subjects with a healthy stomach (Ctr-HS). Sera were analysed
                      using Hp-multiplex serology assay allowing simultaneous
                      detection of antibodies to 13 Hp-proteins. Overall
                      positivity cutoff: seroreactivity to more than 3
                      Hp-antigens.The number of seroreactive Hp-antigens was
                      higher in AAG than in Ctr-HS(mean±SEM 2.2±0.3 vs
                      1.4±0.22,p=0.02) and lower than in Ctr-NAG-Hp+ patients
                      (mean±SEM 5.4±0.5,p<0.001).Overall Hp-seropositivity in
                      AAG was two-fold higher than in Ctr-HS but not statistically
                      significant $(21.1\%$ vs $10.3\%,p=0.06)$ and lower than in
                      $Ctr-NAG-Hp+(80\%,p<0.0001).$ Complete absence of
                      seroreactivity was similar in AAG and Ctr-HS $(29.3\%$ vs
                      $38.5\%,$ p=0.23) and significantly higher than in
                      Ctr-NAG-Hp+ $(4\%,$ p=0.009). Main immunogenic Hp-proteins
                      were
                      HP0010(GroEL),HP1098(HcpC),HP0695(HyuA),HP0875(Catalase),HP1564,HP0547(CagA)
                      and HP0243(NapA) with seroreactivity in $>50\%$ of AAG
                      patients.By Hp-multiplex serology, $30\%$ of histologically
                      Hp-negative AAG pts had no seroreactivity, likely belonging
                      to the pure AAG type. Conversely, $20\%$ of AAG pts showed
                      Hp exposure, indicating that infection might have triggered
                      gastric autoimmunity. The remaining AAG patients showed
                      seroreactivity below cut-off for seropositivity and thus not
                      definitively categorisable by this approach.},
      keywords     = {Atrophic gastritis (Other) / Autoimmune gastritis (Other) /
                      Helicobacter pylori (Other) / Multiplex serology (Other)},
      cin          = {C230},
      ddc          = {610},
      cid          = {I:(DE-He78)C230-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41484031},
      doi          = {10.1016/j.dld.2025.12.002},
      url          = {https://inrepo02.dkfz.de/record/307526},
}