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@ARTICLE{Sagerer:307537,
      author       = {A. Sagerer and I. Y. Eyüpoglu and T. A. Juratli and N.
                      Cordes$^*$},
      title        = {{C}ontext-specific targeting of focal adhesion kinase in
                      brain tumors: lessons from glioblastoma and
                      neurofibromatosis type 2-mutant meningioma.},
      journal      = {Frontiers in oncology},
      volume       = {15},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2026-00042},
      pages        = {1724278},
      year         = {2025},
      abstract     = {Focal adhesion kinase (FAK) has long been explored as a
                      therapeutic target in glioblastoma (GBM) based on its
                      overexpression and involvement in invasive signaling.
                      However, clinical trials have consistently failed to show
                      benefit - highlighting a core principle of translational
                      oncology: target presence alone does not imply therapeutic
                      relevance. In contrast, neurofibromatosis type 2
                      (NF2)-mutant meningiomas present a biologically grounded
                      vulnerability, in which loss of the tumor suppressor
                      moesin-ezrin-radixin-like protein (merlin) creates a
                      synthetic lethal dependency on FAK. This context-specific
                      dependency enables clinically meaningful targeting.
                      Early-phase trials already show promising disease control
                      with favorable safety profiles. This mini review examines
                      the contrasting roles of FAK in GBM and NF2-mutant
                      meningiomas to underscore the importance of biological
                      context in therapeutic decisions. We propose that NF2-mutant
                      meningiomas represent a model for context-specific,
                      synthetic lethal targeting, exemplifying a functional
                      oncogenomics approach to precision oncology.},
      subtyp        = {Review Article},
      keywords     = {FAK inhibitor (Other) / NF2-mutant meningioma (Other) /
                      focal adhesion kinase (Other) / glioblastoma (Other) /
                      pFAK-Y397 (Other) / precision oncology (Other) / synthetic
                      lethality (Other)},
      cin          = {DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41487565},
      pmc          = {pmc:PMC12757307},
      doi          = {10.3389/fonc.2025.1724278},
      url          = {https://inrepo02.dkfz.de/record/307537},
}