TY  - JOUR
AU  - Döhner, Hartmut
AU  - Späth, Daniela
AU  - Saadati, Maral
AU  - Fiedler, Walter
AU  - Götze, Katharina S
AU  - Koller, Elisabeth
AU  - Westermann, Jörg
AU  - Vogel, Wichard
AU  - Heuser, Michael
AU  - Lübbert, Michael
AU  - Tischler, Hans-Joachim
AU  - Germing, Ulrich
AU  - Teichmann, Lino Lars
AU  - Fransecky, Lars
AU  - Wölfler, Albert
AU  - Nachbaur, David
AU  - Hertenstein, Bernd
AU  - Schroers, Roland
AU  - Martens, Uwe M
AU  - von Harsdorf, Stephanie
AU  - Radsak, Markus P
AU  - Aschauer, Gregor
AU  - Weißhaar, Stefanie
AU  - Corbacioglu, Andrea
AU  - Schrade, Anika
AU  - Gaidzik, Verena I
AU  - Thol, Felicitas R
AU  - Paschka, Peter
AU  - Bullinger, Lars
AU  - Benner, Axel
AU  - Döhner, Konstanze
AU  - Ganser, Arnold
TI  - Phase 3 study of intensive chemotherapy with or without dasatinib in core-binding factor acute myeloid leukemia.
JO  - Blood
VL  - nn
SN  - 0006-4971
CY  - Washington, DC
PB  - American Society of Hematology
M1  - DKFZ-2026-00049
SP  - nn
PY  - 2026
N1  - epub
AB  - Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT.We report results from the randomized, open-label, phase 3 trial of intensive chemotherapy with or without the multi-kinase inhibitor dasatinib in adult patients with CBF-AML.Patients received '3+7' induction therapy, followed by 4 cycles of high-dose cytarabine; in the investigational arm, patients received dasatinib 100 mg QD on days 8-21 in induction, and on days 6-28 in consolidation cycles, followed by 12-month single-agent dasatinib 100 mg QD. Primary endpoint was event-free survival (EFS). Secondary endpoints included overall survival, relapse-free survival, and cumulative incidence of relapse.202 patients were randomly assigned to the standard arm (n=102) and to the dasatinib arm (n=100). Median age was 49 years (range, 18, 77); 94 patients had t(8;21), 108 had inv(16)/t(16;16); 58 (28.7
LB  - PUB:(DE-HGF)16
C6  - pmid:41490515
DO  - DOI:10.1182/blood.2025030722
UR  - https://inrepo02.dkfz.de/record/307552
ER  -