%0 Journal Article
%A Park, Jung Won
%A Kwak, Jiehoon
%A Kim, Keon-Woo
%A Jung, Saehoon
%A Nam, Chang Hyun
%A Kim, Hyun Jung
%A Lee, Sang Mee
%A Choi, Chanho
%A Ahn, Yongjin
%A Park, Ji-Hyung
%A Yoo, Jihwan
%A Shim, Jin-Kyoung
%A Cho, Hye Joung
%A Kim, Eui-Hyun
%A Kim, Chungyeul
%A Ahn, Sangjeong
%A Pusch, Stefan
%A von Deimling, Andreas
%A Chang, Jong Hee
%A Kim, Se Hoon
%A Kim, Hoon
%A Ju, Young Seok
%A Kang, Seok-Gu
%A Lee, Jeong Ho
%T IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation.
%J Science
%V 391
%N 6781
%@ 0036-8075
%C Washington, DC
%I American Association for the Advancement of Science
%M DKFZ-2026-00072
%P eadt0559
%D 2026
%Z #DKTKZFB26# / ISSN 1095-9203
%X Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)-mutant gliomas, the most common malignant primary brain tumor in young adults, the cell of origin is currently poorly understood. We conducted deep sequencing on 142 tissues from 70 individuals comprising tumors, peritumoral cortex or subventricular zones, and blood. Low-level IDH mutations were found in the peritumoral cortex in 37.9
%K Isocitrate Dehydrogenase: genetics
%K Glioma: genetics
%K Glioma: pathology
%K Humans
%K Animals
%K Brain Neoplasms: genetics
%K Brain Neoplasms: pathology
%K Mice
%K Mutation
%K Neuroglia: pathology
%K Clonal Evolution
%K Adult
%K Female
%K Male
%K Isocitrate Dehydrogenase (NLM Chemicals)
%K IDH1 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41505555
%R 10.1126/science.adt0559
%U https://inrepo02.dkfz.de/record/307577