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@ARTICLE{Park:307577,
      author       = {J. W. Park and J. Kwak and K.-W. Kim and S. Jung and C. H.
                      Nam and H. J. Kim and S. M. Lee and C. Choi and Y. Ahn and
                      J.-H. Park and J. Yoo and J.-K. Shim and H. J. Cho and E.-H.
                      Kim and C. Kim and S. Ahn and S. Pusch$^*$ and A. von
                      Deimling$^*$ and J. H. Chang and S. H. Kim and H. Kim and Y.
                      S. Ju and S.-G. Kang and J. H. Lee},
      title        = {{IDH}-mutant gliomas arise from glial progenitor cells
                      harboring the initial driver mutation.},
      journal      = {Science},
      volume       = {391},
      number       = {6781},
      issn         = {0036-8075},
      address      = {Washington, DC},
      publisher    = {American Association for the Advancement of Science},
      reportid     = {DKFZ-2026-00072},
      pages        = {eadt0559},
      year         = {2026},
      note         = {#DKTKZFB26# / ISSN 1095-9203},
      abstract     = {Identifying the cell of origin that harbors an initial
                      driver mutation is key to understanding tumor evolution and
                      for the development of new treatments. For isocitrate
                      dehydrogenase (IDH)-mutant gliomas, the most common
                      malignant primary brain tumor in young adults, the cell of
                      origin is currently poorly understood. We conducted deep
                      sequencing on 142 tissues from 70 individuals comprising
                      tumors, peritumoral cortex or subventricular zones, and
                      blood. Low-level IDH mutations were found in the peritumoral
                      cortex in $37.9\%$ (11 of 29) of patients. Integrating
                      cell-type-specific mutation analysis, the direction of
                      clonal evolution, spatial transcriptomics from patient
                      brains, and a cancer mouse model arising from mutant
                      oligodendrocyte progenitor cell, we determined that glial
                      progenitor cells harboring an initial IDH mutation were
                      responsible for the development of IDH-mutant gliomas.},
      keywords     = {Isocitrate Dehydrogenase: genetics / Glioma: genetics /
                      Glioma: pathology / Humans / Animals / Brain Neoplasms:
                      genetics / Brain Neoplasms: pathology / Mice / Mutation /
                      Neuroglia: pathology / Clonal Evolution / Adult / Female /
                      Male / Isocitrate Dehydrogenase (NLM Chemicals) / IDH1
                      protein, human (NLM Chemicals)},
      cin          = {B300 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41505555},
      doi          = {10.1126/science.adt0559},
      url          = {https://inrepo02.dkfz.de/record/307577},
}