TY  - JOUR
AU  - Riedmeier, Maria
AU  - Frey, Heidi
AU  - Antonini, Sonir R
AU  - Canali, Gabriela Fernandes Luiz
AU  - Classen, Carl Friedrich
AU  - Domínguez-Pinilla, Nerea
AU  - Fassnacht, Martin
AU  - Finger, Jasmin
AU  - Fuchs, Steffen
AU  - Grönroos, Marika
AU  - Halah, Mariana P
AU  - Härtel, Christoph
AU  - Janus, Dominika
AU  - Jaspers-Bakker, Antoinette
AU  - de Krijger, Ronald R
AU  - Kutluk, Tezer
AU  - Mezoued, Mouna
AU  - Munarin, Jessica
AU  - van Noesel, Max
AU  - Köse, Nihal Özdemir
AU  - Pearce, Simon H
AU  - Perwein, Thomas
AU  - Puglisi, Soraya
AU  - Schlegel, Paul-Gerhardt
AU  - Binder-Blaser, Vera
AU  - Tuli, Gerdi
AU  - Walenciak, Justyna
AU  - Yalcin, Bilgehan
AU  - Wiegering, Verena
TI  - Mitotane dosage, plasma levels, and anthropometric measurements in pediatric adrenocortical carcinoma.
JO  - Endocrine oncology
VL  - 6
IS  - 1
SN  - 2634-4793
CY  - [Bristol]
PB  - Bioscientifica Ltd.
M1  - DKFZ-2026-00076
SP  - e240081
PY  - 2026
N1  - #DKTKZFB9#
AB  - Mitotane is an effective treatment for advanced adrenocortical carcinoma (ACC). Given the limited pediatric data available, this study aims to evaluate the associations between mitotane dosage, plasma drug levels, and anthropometric measurements, as well as their potential impact on dosage requirements to optimize therapeutic outcomes in pediatric patients with ACC (pACC).A retrospective, international, multicenter study was conducted on pediatric ACC patients treated with mitotane across 18 centers. Mitotane serum levels were obtained from the Lysosafe Online® database or directly from the centers. Data from the cohort with plasma levels within the target range (≥14 mg/L; n = 319) were analyzed and compared to those with levels outside this range (n = 320).Fifty pediatric patients (60
KW  - mitotane (Other)
KW  - mitotane dosage (Other)
KW  - mitotane plasma level (Other)
KW  - pediatric adrenocortical carcinoma (Other)
KW  - pediatric adrenocortical tumor (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41503252
C2  - pmc:PMC12771559
DO  - DOI:10.1530/EO-24-0081
UR  - https://inrepo02.dkfz.de/record/307581
ER  -