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@ARTICLE{Ehret:307614,
      author       = {F. Ehret$^*$ and J. Grimm and G. Subedi and S. M. Vorbach
                      and V. Salvestrini and I. Bonaparte and A. A. Mohamed and S.
                      Adebahr$^*$ and A. Richter and A. Fabian and T. Weissmann
                      and J. Kaufmann and S. Drabke and E. L. Looman and M.
                      Waltenberger and K. M. Kraus and M. Grohmann and A. Baehr
                      and S. Rogers and A. Gawish and J.-N. Becker and R. J.
                      Klement and R. Partl and M. J. Eble and A.-L. Grosu$^*$ and
                      A. Rimner$^*$ and E. Gkika$^*$ and M. Trommer and O.
                      Riesterer and F. Putz and U. Ganswindt and C. Moustakis and
                      N. H. Nicolay and T. B. Brunner and O. Blanck and P. Bonomo
                      and A. Wittig-Sauerwein and P. Balermpas and F. Nägler and
                      A. Rühle$^*$},
      title        = {{T}umor control probability modeling of pulmonary
                      metastases in oligometastatic head and neck squamous cell
                      carcinoma treated with stereotactic body radiation therapy.},
      journal      = {Radiotherapy and oncology},
      volume       = {nn},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2026-00086},
      pages        = {nn},
      year         = {2026},
      note         = {#DKTKZFB9# / epub},
      abstract     = {Local control rates for pulmonary metastases from head and
                      neck squamous cell carcinoma (HNSCC) treated with
                      stereotactic body radiation therapy (SBRT) vary
                      substantially in the literature, likely due to differences
                      in the doses applied. This study, therefore, aims to develop
                      tumor control probability (TCP) models.Dose-time modeling of
                      TCP was performed for three key dose descriptors: 3-fraction
                      equivalent dose (3fxED) prescription dose, 3fxED planning
                      target volume (PTV) $D95\%,$ and 3fxED PTV $D2\%.$ Each dose
                      descriptor was stratified into 4 dose groups using a
                      k-medians clustering algorithm, and the Kaplan-Meier
                      estimator was computed in each group separately to enable
                      time-dependent dose-response modeling. Logistic regression
                      models were fitted using maximum likelihood estimation with
                      model parameters determined separately for 1-year and 2-year
                      local control.This retrospective multicenter analysis
                      included 318 pulmonary metastases from 215 patients. The
                      median 3fxED prescription dose was 45.0 Gy (IQR, 39.2-46.5),
                      corresponding to a biologically effective dose (α/β = 20
                      Gy) (BED20) of 78.8 Gy (IQR, 64.8-82.5). After a median
                      radiographic follow-up of 13.3 months (IQR, 6.6-32.0), 21
                      local failures were observed. All models indicated a
                      dose-dependent effect on the local control probability. A
                      local control rate of 95 $\%$ was achieved at 1 and 2 years
                      when 3fxED prescription doses and PTV $D95\%$ exceeded about
                      51 Gy (94 Gy BED20), and when PTV $D2\%$ reached 66 Gy (139
                      Gy BED20).These TCP models suggest a dose-dependent
                      probability of local control in pulmonary HNSCC metastases
                      treated with SBRT and provide a basis for future clinical
                      assessments in this population.},
      keywords     = {Head and neck cancer (Other) / Lung metastases (Other) /
                      Modeling (Other) / Oligometastases (Other) / Radiotherapy
                      (Other) / SABR (Other) / SBRT (Other) / Stereotactic body
                      radiation therapy (Other) / Tumor control probability
                      (Other)},
      cin          = {BE01 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41519167},
      doi          = {10.1016/j.radonc.2026.111375},
      url          = {https://inrepo02.dkfz.de/record/307614},
}