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@ARTICLE{Lawatsch:307634,
      author       = {L. Lawatsch and M. Baier and T. Milde$^*$ and B. Gruhn},
      title        = {{S}ignificance of parvovirus {B}19 infection in childhood -
                      collection of demographic data, clinical presentation,
                      diagnostic findings and the impact on patients with
                      hemolytic anemia.},
      journal      = {Diagnostic microbiology and infectious disease},
      volume       = {114},
      number       = {4},
      issn         = {0732-8893},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2026-00105},
      pages        = {117263},
      year         = {2026},
      abstract     = {Parvovirus B19 is a known cause of erythema infectiosum,
                      aplastic crises and severe anemia, especially in patients
                      with hemolytic anemia. The aim of this study was to
                      investigate the clinical and diagnostic parameters of
                      parvovirus B19 infection in children with and without
                      hemolytic anemia and to record the course of case numbers in
                      recent years.We retrospectively included all patients
                      diagnosed with acute parvovirus B19 infection at the
                      Department of Pediatrics, Jena University Hospital, Jena,
                      Germany between 2016 and 2024. Diagnosis was confirmed by
                      positive parvovirus B19 IgM serology and/or PCR testing.
                      Both demographic and clinical data as well as diagnostic
                      parameters were collected and analyzed, focusing on
                      differences between children with and without underlying
                      hemolytic anemia.Among the 40 pediatric patients included in
                      this study, 14 patients were diagnosed with hemolytic
                      anemia. Children with hemolytic anemia suffered from a
                      significantly greater hemoglobin drop and a significantly
                      higher need for transfusion compared to children without
                      hemolytic anemia. A Poisson regression model, adjusted for
                      observation time, was used to compare case rates between
                      2016 and 2022 and 2023-2024.The model demonstrated a more
                      than fivefold increase in parvovirus B19 cases in 2023-2024
                      compared to 2016-2022.Children with hemolytic anemia, such
                      as spherocytosis, are at higher risk of severe anemia and
                      require more frequently transfusions during acute parvovirus
                      B19 infection. The observed increase in cases after 2022
                      suggests changing epidemiological patterns and highlights
                      the need for careful surveillance and early diagnostic and
                      therapeutic interventions in affected children.},
      keywords     = {Acute anemia (Other) / Erythema infectiosum (Other) /
                      Hemolytic anemia (Other) / Hemolytic disorders (Other) / IgM
                      antibodies (Other) / PCR (Other) / Parvovirus B19 (Other) /
                      Pediatric hematology (Other) / Pediatric infection (Other)},
      cin          = {B310},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41529596},
      doi          = {10.1016/j.diagmicrobio.2026.117263},
      url          = {https://inrepo02.dkfz.de/record/307634},
}