%0 Journal Article
%A Hernández-Sánchez, Alberto
%A Villaverde Ramiro, Ángela
%A Sträng, Eric
%A Turki, Amin T
%A Abáigar, María
%A Versluis, Jurjen
%A Thomas, Ian
%A Sobas, Marta
%A Martínez Elicegui, Javier
%A Castellani, Gastone
%A Benner, Axel
%A Azibeiro, Raúl
%A Tettero, Jesse M
%A Mecklenbrauck, Rabea
%A Martínez-López, Joaquín
%A Pratcorona, Marta
%A Mills, Ken I
%A Sanz, Guillermo
%A Voso, Maria Teresa
%A Sören, Lehmann
%A Röllig, Christoph
%A Thiede, Christian
%A Metzeler, Klaus H
%A Döhner, Konstanze
%A Heuser, Michael
%A Haferlach, Torsten
%A Valk, Peter Jm
%A Russell, Nigel
%A Hernández-Rivas, Jesús María
%A Huntly, Brian
%A Ossenkoppele, Gert
%A Döhner, Hartmut
%A Bullinger, Lars
%T Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study.
%J Leukemia
%V nn
%@ 0887-6924
%C London
%I Springer Nature
%M DKFZ-2026-00115
%P nn
%D 2026
%Z #DKTKZFB26# / epub
%X NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database. A newly developed risk classification, which included combinations of co-mutations in FLT3-ITD, DNMT3A, IDH1/IDH2, and TET2 genes, was applied to a training cohort of NPM1-mut AML patients included in clinical trials (n = 1001), an internal validation cohort more representative of real-world settings (n = 762), and an external validation cohort enrolled in UK-NCRI trials (n = 585). The HARMONY classification considered 51.8
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41535568
%R 10.1038/s41375-025-02851-9
%U https://inrepo02.dkfz.de/record/307654