TY  - JOUR
AU  - Hernández-Sánchez, Alberto
AU  - Villaverde Ramiro, Ángela
AU  - Sträng, Eric
AU  - Turki, Amin T
AU  - Abáigar, María
AU  - Versluis, Jurjen
AU  - Thomas, Ian
AU  - Sobas, Marta
AU  - Martínez Elicegui, Javier
AU  - Castellani, Gastone
AU  - Benner, Axel
AU  - Azibeiro, Raúl
AU  - Tettero, Jesse M
AU  - Mecklenbrauck, Rabea
AU  - Martínez-López, Joaquín
AU  - Pratcorona, Marta
AU  - Mills, Ken I
AU  - Sanz, Guillermo
AU  - Voso, Maria Teresa
AU  - Sören, Lehmann
AU  - Röllig, Christoph
AU  - Thiede, Christian
AU  - Metzeler, Klaus H
AU  - Döhner, Konstanze
AU  - Heuser, Michael
AU  - Haferlach, Torsten
AU  - Valk, Peter Jm
AU  - Russell, Nigel
AU  - Hernández-Rivas, Jesús María
AU  - Huntly, Brian
AU  - Ossenkoppele, Gert
AU  - Döhner, Hartmut
AU  - Bullinger, Lars
TI  - Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study.
JO  - Leukemia
VL  - nn
SN  - 0887-6924
CY  - London
PB  - Springer Nature
M1  - DKFZ-2026-00115
SP  - nn
PY  - 2026
N1  - #DKTKZFB26# / epub
AB  - NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database. A newly developed risk classification, which included combinations of co-mutations in FLT3-ITD, DNMT3A, IDH1/IDH2, and TET2 genes, was applied to a training cohort of NPM1-mut AML patients included in clinical trials (n = 1001), an internal validation cohort more representative of real-world settings (n = 762), and an external validation cohort enrolled in UK-NCRI trials (n = 585). The HARMONY classification considered 51.8
LB  - PUB:(DE-HGF)16
C6  - pmid:41535568
DO  - DOI:10.1038/s41375-025-02851-9
UR  - https://inrepo02.dkfz.de/record/307654
ER  -