%0 Journal Article
%A Bernardi, Flavia
%A Torrejon, Jacob
%A Basili, Irene
%A Van Ommeren, Randy
%A Marsaud, Véronique
%A Yu, Hua
%A Talbot, Julie
%A Souphron, Judith
%A Indersie, Emilie
%A Forget, Antoine
%A Bonneau, Benjamin
%A Massiot, Alexane
%A Alcazar, Coralie
%A Figeac, Laurine
%A Bonerandi, Emma
%A Cancila, Gabriele
%A Sirbu, Olga
%A Yadav, Navneesh
%A Mohanakrishnan, Dinesh
%A Lombard, Bérangère
%A Loew, Damarys
%A Poullet, Patrick
%A Liva, Stephane
%A Lovino, Marta
%A Lin, I-Hsuan
%A Nakashima, Takuma
%A Gharsalli, Tarek
%A Nicolas, Paul Antoine
%A Yubuki, Naoji
%A Ribas, Roberto A
%A Colsch, Benoit
%A Chu-Van, Emeline
%A Castelli, Florence
%A Sampaio, Julio Lopes
%A Leboucher, Sophie
%A Lasgi, Charlene
%A Besse, Laetitia
%A Soler, Marie-Noëlle
%A Lo Re, Valentina
%A Planque, Nathalie
%A Abeysundara, Namal
%A Balin, Polina
%A Wang, Hao
%A Su, Haipeng
%A Wu, Xiaochong
%A Cavalli, Florence M G
%A Saulnier, Olivier
%A Ficarra, Elisa
%A Di Marcotullio, Lucia
%A Kumegawa, Kohei
%A Maruyama, Reo
%A Kawauchi, Daisuke
%A Picard, Daniel
%A Remke, Marc
%A Riffaud, Laurent
%A Puiseux, Chloé
%A Bouchoucha, Yassine
%A Huybrechts, Sophie
%A Simbozel, Marie
%A Bourdeaut, Franck
%A Varlet, Pascale
%A Puget, Stéphanie
%A Blauwblomme, Thomas
%A Andrianteranagna, Mamy
%A Planchon, Julien Masliah
%A Dugourd, Aurelien
%A Saez-Rodriguez, Julio
%A Barillot, Emmanuel
%A Servant, Nicolas
%A Martignetti, Loredana
%A Rich, Jeremy
%A Kool, Marcel
%A Pfister, Stefan M
%A Agnihotri, Sameer
%A Suzuki, Hiromichi
%A Fanjul, Marjorie
%A Wang, Won-Jing
%A Tsai, Jin-Wu
%A Sun, Ramon C
%A Beccaria, Kévin
%A Dufour, Christelle
%A Sarry, Jean-Emmanuel
%A Michealraj, Kulandaimanuvel Antony
%A Taylor, Michael D
%A Ayrault, Olivier
%T Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
%J Cancer cell
%V nn
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2026-00133
%P nn
%D 2026
%Z #DKTKZFB26# / #NCTZFB26# / epub
%X Medulloblastoma, the most common malignant brain tumor of childhood, exhibits significant biological complexity that demands deeper exploration. Here, we present a large multiomics dataset integrating data from 384 primary medulloblastoma patient samples across five omic layers: CpG methylome, transcriptome, proteome, phosphoproteome, and metabolome, paired with associated clinical metadata. Data integration revealed intertumoral heterogeneity of lipid metabolism across proteomic subtypes. Notably, while the MYC-FASN-SCD axis drives lipid biosynthesis, pathway inhibition elicits a compensatory escape mechanism in vivo through exogenous fatty acid uptake. Unexpectedly, we demonstrated that MYC triggers lipid storage, creating a unique dependency on lipid droplet-mitochondria communications to sustain tumor maintenance in vivo. Together, this comprehensive analysis reveals a targetable vulnerability downstream of MYC that constitutes a promising therapeutic approach to treat currently untreatable medulloblastoma subtypes.
%K lipid biosynthesis (Other)
%K lipid droplets (Other)
%K lipid oxidative stress (Other)
%K medulloblastoma (Other)
%K metabolomics (Other)
%K multiomics integration (Other)
%K pediatric cancer (Other)
%K phosphoproteomics (Other)
%K proteomics (Other)
%K transcriptomics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41544627
%R 10.1016/j.ccell.2025.12.012
%U https://inrepo02.dkfz.de/record/308493