000308493 001__ 308493
000308493 005__ 20260119142654.0
000308493 0247_ $$2doi$$a10.1016/j.ccell.2025.12.012
000308493 0247_ $$2pmid$$apmid:41544627
000308493 0247_ $$2ISSN$$a1535-6108
000308493 0247_ $$2ISSN$$a1878-3686
000308493 037__ $$aDKFZ-2026-00133
000308493 041__ $$aEnglish
000308493 082__ $$a610
000308493 1001_ $$aBernardi, Flavia$$b0
000308493 245__ $$aMultiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
000308493 260__ $$aCambridge, Mass.$$bCell Press$$c2026
000308493 3367_ $$2DRIVER$$aarticle
000308493 3367_ $$2DataCite$$aOutput Types/Journal article
000308493 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1768829147_2109350
000308493 3367_ $$2BibTeX$$aARTICLE
000308493 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000308493 3367_ $$00$$2EndNote$$aJournal Article
000308493 500__ $$a#DKTKZFB26# / #NCTZFB26# / epub
000308493 520__ $$aMedulloblastoma, the most common malignant brain tumor of childhood, exhibits significant biological complexity that demands deeper exploration. Here, we present a large multiomics dataset integrating data from 384 primary medulloblastoma patient samples across five omic layers: CpG methylome, transcriptome, proteome, phosphoproteome, and metabolome, paired with associated clinical metadata. Data integration revealed intertumoral heterogeneity of lipid metabolism across proteomic subtypes. Notably, while the MYC-FASN-SCD axis drives lipid biosynthesis, pathway inhibition elicits a compensatory escape mechanism in vivo through exogenous fatty acid uptake. Unexpectedly, we demonstrated that MYC triggers lipid storage, creating a unique dependency on lipid droplet-mitochondria communications to sustain tumor maintenance in vivo. Together, this comprehensive analysis reveals a targetable vulnerability downstream of MYC that constitutes a promising therapeutic approach to treat currently untreatable medulloblastoma subtypes.
000308493 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000308493 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000308493 650_7 $$2Other$$alipid biosynthesis
000308493 650_7 $$2Other$$alipid droplets
000308493 650_7 $$2Other$$alipid oxidative stress
000308493 650_7 $$2Other$$amedulloblastoma
000308493 650_7 $$2Other$$ametabolomics
000308493 650_7 $$2Other$$amultiomics integration
000308493 650_7 $$2Other$$apediatric cancer
000308493 650_7 $$2Other$$aphosphoproteomics
000308493 650_7 $$2Other$$aproteomics
000308493 650_7 $$2Other$$atranscriptomics
000308493 7001_ $$aTorrejon, Jacob$$b1
000308493 7001_ $$aBasili, Irene$$b2
000308493 7001_ $$aVan Ommeren, Randy$$b3
000308493 7001_ $$aMarsaud, Véronique$$b4
000308493 7001_ $$aYu, Hua$$b5
000308493 7001_ $$aTalbot, Julie$$b6
000308493 7001_ $$aSouphron, Judith$$b7
000308493 7001_ $$aIndersie, Emilie$$b8
000308493 7001_ $$aForget, Antoine$$b9
000308493 7001_ $$aBonneau, Benjamin$$b10
000308493 7001_ $$aMassiot, Alexane$$b11
000308493 7001_ $$aAlcazar, Coralie$$b12
000308493 7001_ $$aFigeac, Laurine$$b13
000308493 7001_ $$aBonerandi, Emma$$b14
000308493 7001_ $$aCancila, Gabriele$$b15
000308493 7001_ $$aSirbu, Olga$$b16
000308493 7001_ $$aYadav, Navneesh$$b17
000308493 7001_ $$aMohanakrishnan, Dinesh$$b18
000308493 7001_ $$aLombard, Bérangère$$b19
000308493 7001_ $$aLoew, Damarys$$b20
000308493 7001_ $$aPoullet, Patrick$$b21
000308493 7001_ $$aLiva, Stephane$$b22
000308493 7001_ $$aLovino, Marta$$b23
000308493 7001_ $$aLin, I-Hsuan$$b24
000308493 7001_ $$aNakashima, Takuma$$b25
000308493 7001_ $$aGharsalli, Tarek$$b26
000308493 7001_ $$aNicolas, Paul Antoine$$b27
000308493 7001_ $$aYubuki, Naoji$$b28
000308493 7001_ $$aRibas, Roberto A$$b29
000308493 7001_ $$aColsch, Benoit$$b30
000308493 7001_ $$aChu-Van, Emeline$$b31
000308493 7001_ $$aCastelli, Florence$$b32
000308493 7001_ $$aSampaio, Julio Lopes$$b33
000308493 7001_ $$aLeboucher, Sophie$$b34
000308493 7001_ $$aLasgi, Charlene$$b35
000308493 7001_ $$aBesse, Laetitia$$b36
000308493 7001_ $$aSoler, Marie-Noëlle$$b37
000308493 7001_ $$aLo Re, Valentina$$b38
000308493 7001_ $$aPlanque, Nathalie$$b39
000308493 7001_ $$aAbeysundara, Namal$$b40
000308493 7001_ $$aBalin, Polina$$b41
000308493 7001_ $$aWang, Hao$$b42
000308493 7001_ $$aSu, Haipeng$$b43
000308493 7001_ $$aWu, Xiaochong$$b44
000308493 7001_ $$aCavalli, Florence M G$$b45
000308493 7001_ $$aSaulnier, Olivier$$b46
000308493 7001_ $$aFicarra, Elisa$$b47
000308493 7001_ $$aDi Marcotullio, Lucia$$b48
000308493 7001_ $$aKumegawa, Kohei$$b49
000308493 7001_ $$aMaruyama, Reo$$b50
000308493 7001_ $$aKawauchi, Daisuke$$b51
000308493 7001_ $$aPicard, Daniel$$b52
000308493 7001_ $$aRemke, Marc$$b53
000308493 7001_ $$aRiffaud, Laurent$$b54
000308493 7001_ $$aPuiseux, Chloé$$b55
000308493 7001_ $$aBouchoucha, Yassine$$b56
000308493 7001_ $$aHuybrechts, Sophie$$b57
000308493 7001_ $$aSimbozel, Marie$$b58
000308493 7001_ $$aBourdeaut, Franck$$b59
000308493 7001_ $$aVarlet, Pascale$$b60
000308493 7001_ $$aPuget, Stéphanie$$b61
000308493 7001_ $$aBlauwblomme, Thomas$$b62
000308493 7001_ $$aAndrianteranagna, Mamy$$b63
000308493 7001_ $$aPlanchon, Julien Masliah$$b64
000308493 7001_ $$aDugourd, Aurelien$$b65
000308493 7001_ $$aSaez-Rodriguez, Julio$$b66
000308493 7001_ $$aBarillot, Emmanuel$$b67
000308493 7001_ $$aServant, Nicolas$$b68
000308493 7001_ $$aMartignetti, Loredana$$b69
000308493 7001_ $$aRich, Jeremy$$b70
000308493 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b71$$udkfz
000308493 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b72$$udkfz
000308493 7001_ $$aAgnihotri, Sameer$$b73
000308493 7001_ $$aSuzuki, Hiromichi$$b74
000308493 7001_ $$aFanjul, Marjorie$$b75
000308493 7001_ $$aWang, Won-Jing$$b76
000308493 7001_ $$aTsai, Jin-Wu$$b77
000308493 7001_ $$aSun, Ramon C$$b78
000308493 7001_ $$aBeccaria, Kévin$$b79
000308493 7001_ $$aDufour, Christelle$$b80
000308493 7001_ $$aSarry, Jean-Emmanuel$$b81
000308493 7001_ $$aMichealraj, Kulandaimanuvel Antony$$b82
000308493 7001_ $$aTaylor, Michael D$$b83
000308493 7001_ $$aAyrault, Olivier$$b84
000308493 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2025.12.012$$gp. S153561082500546X$$pnn$$tCancer cell$$vnn$$x1535-6108$$y2026
000308493 909CO $$ooai:inrepo02.dkfz.de:308493$$pVDB
000308493 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aDeutsches Krebsforschungszentrum$$b71$$kDKFZ
000308493 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b72$$kDKFZ
000308493 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000308493 9141_ $$y2026
000308493 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCER CELL : 2022$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-20
000308493 915__ $$0StatID:(DE-HGF)9950$$2StatID$$aIF >= 50$$bCANCER CELL : 2022$$d2024-12-20
000308493 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x0
000308493 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000308493 9201_ $$0I:(DE-He78)HD02-20160331$$kHD02$$lKoordinierungsstelle NCT Heidelberg$$x2
000308493 980__ $$ajournal
000308493 980__ $$aVDB
000308493 980__ $$aI:(DE-He78)B062-20160331
000308493 980__ $$aI:(DE-He78)HD01-20160331
000308493 980__ $$aI:(DE-He78)HD02-20160331
000308493 980__ $$aUNRESTRICTED