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@ARTICLE{Bernardi:308493,
      author       = {F. Bernardi and J. Torrejon and I. Basili and R. Van
                      Ommeren and V. Marsaud and H. Yu and J. Talbot and J.
                      Souphron and E. Indersie and A. Forget and B. Bonneau and A.
                      Massiot and C. Alcazar and L. Figeac and E. Bonerandi and G.
                      Cancila and O. Sirbu and N. Yadav and D. Mohanakrishnan and
                      B. Lombard and D. Loew and P. Poullet and S. Liva and M.
                      Lovino and I.-H. Lin and T. Nakashima and T. Gharsalli and
                      P. A. Nicolas and N. Yubuki and R. A. Ribas and B. Colsch
                      and E. Chu-Van and F. Castelli and J. L. Sampaio and S.
                      Leboucher and C. Lasgi and L. Besse and M.-N. Soler and V.
                      Lo Re and N. Planque and N. Abeysundara and P. Balin and H.
                      Wang and H. Su and X. Wu and F. M. G. Cavalli and O.
                      Saulnier and E. Ficarra and L. Di Marcotullio and K.
                      Kumegawa and R. Maruyama and D. Kawauchi and D. Picard and
                      M. Remke and L. Riffaud and C. Puiseux and Y. Bouchoucha and
                      S. Huybrechts and M. Simbozel and F. Bourdeaut and P. Varlet
                      and S. Puget and T. Blauwblomme and M. Andrianteranagna and
                      J. M. Planchon and A. Dugourd and J. Saez-Rodriguez and E.
                      Barillot and N. Servant and L. Martignetti and J. Rich and
                      M. Kool$^*$ and S. M. Pfister$^*$ and S. Agnihotri and H.
                      Suzuki and M. Fanjul and W.-J. Wang and J.-W. Tsai and R. C.
                      Sun and K. Beccaria and C. Dufour and J.-E. Sarry and K. A.
                      Michealraj and M. D. Taylor and O. Ayrault},
      title        = {{M}ultiomic integration reveals tumoral heterogeneity of
                      lipid dependence within lethal group 3 medulloblastoma.},
      journal      = {Cancer cell},
      volume       = {nn},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2026-00133},
      pages        = {nn},
      year         = {2026},
      note         = {#DKTKZFB26# / #NCTZFB26# / epub},
      abstract     = {Medulloblastoma, the most common malignant brain tumor of
                      childhood, exhibits significant biological complexity that
                      demands deeper exploration. Here, we present a large
                      multiomics dataset integrating data from 384 primary
                      medulloblastoma patient samples across five omic layers: CpG
                      methylome, transcriptome, proteome, phosphoproteome, and
                      metabolome, paired with associated clinical metadata. Data
                      integration revealed intertumoral heterogeneity of lipid
                      metabolism across proteomic subtypes. Notably, while the
                      MYC-FASN-SCD axis drives lipid biosynthesis, pathway
                      inhibition elicits a compensatory escape mechanism in vivo
                      through exogenous fatty acid uptake. Unexpectedly, we
                      demonstrated that MYC triggers lipid storage, creating a
                      unique dependency on lipid droplet-mitochondria
                      communications to sustain tumor maintenance in vivo.
                      Together, this comprehensive analysis reveals a targetable
                      vulnerability downstream of MYC that constitutes a promising
                      therapeutic approach to treat currently untreatable
                      medulloblastoma subtypes.},
      keywords     = {lipid biosynthesis (Other) / lipid droplets (Other) / lipid
                      oxidative stress (Other) / medulloblastoma (Other) /
                      metabolomics (Other) / multiomics integration (Other) /
                      pediatric cancer (Other) / phosphoproteomics (Other) /
                      proteomics (Other) / transcriptomics (Other)},
      cin          = {B062 / HD01 / HD02},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)HD02-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41544627},
      doi          = {10.1016/j.ccell.2025.12.012},
      url          = {https://inrepo02.dkfz.de/record/308493},
}