%0 Journal Article
%A Lakes, Jale
%A Boschheidgen, Matthias
%A Antoch, Gerald
%A Klett, Maike K
%A Karger, André
%A Roth, Regina
%A Redler, Silke
%A Pai, Mangalore G
%A Wieczorek, Dagmar
%A Jäger, Bernadette
%A Fehm, Tanja N
%A Niegisch, Günter
%A Rau, Tilman T
%A Albers, Peter
%T Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective 'ProFam-Risk' Study.
%J European urology open science
%V 84
%@ 2666-1691
%C [Amsterdam]
%I Elsevier ScienceDirect
%M DKFZ-2026-00174
%P 13 - 21
%D 2026
%Z #LA:C130#
%X Familial and genetic factors influence prostate cancer (PCa) risk, necessitating personalized prevention strategies. This study aims to establish and validate a prevention clinic (ProFam-Risk) for men with a familial or genetic risk of PCa, focusing on genetic testing, multiparametric magnetic resonance imaging (mpMRI), and psychosocial assessment. ProFam-Risk is a prospective registry and outpatient clinic at the University Hospital Düsseldorf, recruiting participants into three groups: healthy men with a familial risk (having two or more affected relatives or early-onset PCa), men with pathogenic germline variants (eg, BRCA1/2), and PCa-affected men meeting familial/genetic criteria. Participants undergo prostate-specific antigen testing, mpMRI, genetic analysis, psychosocial assessment, and receive risk-adapted recommendations for cancer prevention. Outcome measures include prevalence of pathogenic variants, PCa detection rates, and the impact of genetic counseling and mpMRI on clinical decision-making.
%K Genetic risk (Other)
%K Multiparametric magnetic resonance imaging (Other)
%K Pathogenic germline variants (Other)
%K Personalized screening (Other)
%K Prostate cancer (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41561489
%2 pmc:PMC12814690
%R 10.1016/j.euros.2025.12.018
%U https://inrepo02.dkfz.de/record/308548