TY  - JOUR
AU  - Lakes, Jale
AU  - Boschheidgen, Matthias
AU  - Antoch, Gerald
AU  - Klett, Maike K
AU  - Karger, André
AU  - Roth, Regina
AU  - Redler, Silke
AU  - Pai, Mangalore G
AU  - Wieczorek, Dagmar
AU  - Jäger, Bernadette
AU  - Fehm, Tanja N
AU  - Niegisch, Günter
AU  - Rau, Tilman T
AU  - Albers, Peter
TI  - Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective 'ProFam-Risk' Study.
JO  - European urology open science
VL  - 84
SN  - 2666-1691
CY  - [Amsterdam]
PB  - Elsevier ScienceDirect
M1  - DKFZ-2026-00174
SP  - 13 - 21
PY  - 2026
N1  - #LA:C130#
AB  - Familial and genetic factors influence prostate cancer (PCa) risk, necessitating personalized prevention strategies. This study aims to establish and validate a prevention clinic (ProFam-Risk) for men with a familial or genetic risk of PCa, focusing on genetic testing, multiparametric magnetic resonance imaging (mpMRI), and psychosocial assessment. ProFam-Risk is a prospective registry and outpatient clinic at the University Hospital Düsseldorf, recruiting participants into three groups: healthy men with a familial risk (having two or more affected relatives or early-onset PCa), men with pathogenic germline variants (eg, BRCA1/2), and PCa-affected men meeting familial/genetic criteria. Participants undergo prostate-specific antigen testing, mpMRI, genetic analysis, psychosocial assessment, and receive risk-adapted recommendations for cancer prevention. Outcome measures include prevalence of pathogenic variants, PCa detection rates, and the impact of genetic counseling and mpMRI on clinical decision-making.
KW  - Genetic risk (Other)
KW  - Multiparametric magnetic resonance imaging (Other)
KW  - Pathogenic germline variants (Other)
KW  - Personalized screening (Other)
KW  - Prostate cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41561489
C2  - pmc:PMC12814690
DO  - DOI:10.1016/j.euros.2025.12.018
UR  - https://inrepo02.dkfz.de/record/308548
ER  -