Home > Publications database > Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective 'ProFam-Risk' Study. > print

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041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lakes, Jale
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245 _ _ |a Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective 'ProFam-Risk' Study.
260 _ _ |a [Amsterdam]
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520 _ _ |a Familial and genetic factors influence prostate cancer (PCa) risk, necessitating personalized prevention strategies. This study aims to establish and validate a prevention clinic (ProFam-Risk) for men with a familial or genetic risk of PCa, focusing on genetic testing, multiparametric magnetic resonance imaging (mpMRI), and psychosocial assessment. ProFam-Risk is a prospective registry and outpatient clinic at the University Hospital Düsseldorf, recruiting participants into three groups: healthy men with a familial risk (having two or more affected relatives or early-onset PCa), men with pathogenic germline variants (eg, BRCA1/2), and PCa-affected men meeting familial/genetic criteria. Participants undergo prostate-specific antigen testing, mpMRI, genetic analysis, psychosocial assessment, and receive risk-adapted recommendations for cancer prevention. Outcome measures include prevalence of pathogenic variants, PCa detection rates, and the impact of genetic counseling and mpMRI on clinical decision-making.
536 _ _ |a 313 - Krebsrisikofaktoren und Prävention (POF4-313)
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650 _ 7 |a Genetic risk
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650 _ 7 |a Multiparametric magnetic resonance imaging
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650 _ 7 |a Pathogenic germline variants
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650 _ 7 |a Personalized screening
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650 _ 7 |a Prostate cancer
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700 1 _ |a Boschheidgen, Matthias
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700 1 _ |a Antoch, Gerald
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700 1 _ |a Klett, Maike K
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700 1 _ |a Karger, André
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700 1 _ |a Roth, Regina
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700 1 _ |a Redler, Silke
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700 1 _ |a Pai, Mangalore G
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700 1 _ |a Wieczorek, Dagmar
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700 1 _ |a Jäger, Bernadette
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700 1 _ |a Fehm, Tanja N
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700 1 _ |a Niegisch, Günter
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700 1 _ |a Rau, Tilman T
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700 1 _ |a Albers, Peter
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773 _ _ |a 10.1016/j.euros.2025.12.018
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