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000308670 1001_ $$aGabriel, Kathrin$$b0
000308670 245__ $$aThe role of cytokines in cytokine release syndrome (CRS) after CAR T cell therapy.
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000308670 520__ $$aChimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape for hematological malignancies. However, cytokine release syndrome (CRS) remains a common and potentially severe toxicity, significantly affecting patient safety and requiring intensive clinical management. This review provides a focused synthesis on the role of cytokines in CRS after CAR T cell therapy, integrating recent mechanistic insights with clinical implications. We delineate the cellular and molecular pathways involving key cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF), describing their sources, downstream signaling events, and effects on target tissues. By bridging basic cytokine biology with clinical aspects and therapeutic strategies, this review aims to provide a comprehensive framework for understanding the role of cytokines in CRS pathophysiology, ultimately supporting the development of safer and more effective CAR T cell therapies.
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000308670 7001_ $$aHeinzerling, Lucie$$b1
000308670 7001_ $$0P:(DE-HGF)0$$avon Baumgarten, Louisa$$b2
000308670 7001_ $$0P:(DE-HGF)0$$aSubklewe, Marion$$b3
000308670 7001_ $$0P:(DE-HGF)0$$aKobold, Sebastian$$b4
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