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| 001 | 309606 | ||
| 005 | 20260202120628.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2026.01.003 |2 doi |
| 024 | 7 | _ | |a pmid:41616773 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2026-00256 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Haist, Maximilian |b 0 |
| 245 | _ | _ | |a Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2026 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1770021840_1557475 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a epub |
| 520 | _ | _ | |a Lymph node (LN) colonization in cancer is linked to poor prognosis. Evidence suggests that LN colonization induces systemic immunosuppression, facilitating distant metastasis. We investigated LN-mediated immunosuppression in patients with head-and-neck cancer using spatial proteomics, spatial transcriptomics, and an in vivo model of melanoma LN metastasis. Both primary tumors and paired LNs of nodal-positive patients exhibit enhanced interferon-γ signaling and an enrichment of immunosuppressive myeloid cells and cancer-associated fibroblasts (CAFs). The spatial intersection of these myeloid-CAF-enriched niches with perifollicular T cell zones and LN follicles is linked to enhanced T cell dysfunction and Treg activation therein, thereby driving architectural LN remodeling. These immune suppressive changes extend to adjacent non-tumor-involved LN regions and nearby tumor-free LNs, but were not detected in LNs of non-cancer patients, reflecting a systemic effect that compromises anti-tumor immunity beyond the tumor-involved LN. Hence, our findings establish LN colonization as an active driver of systemic immunosuppression, facilitating metastatic progression. |
| 536 | _ | _ | |a 311 - Zellbiologie und Tumorbiologie (POF4-311) |0 G:(DE-HGF)POF4-311 |c POF4-311 |f POF IV |x 0 |
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| 650 | _ | 7 | |a cancer-associated fibroblasts |2 Other |
| 650 | _ | 7 | |a head-and-neck cancer |2 Other |
| 650 | _ | 7 | |a immunomodulation |2 Other |
| 650 | _ | 7 | |a lymph nodes |2 Other |
| 650 | _ | 7 | |a metastasis |2 Other |
| 650 | _ | 7 | |a multiplex imaging |2 Other |
| 650 | _ | 7 | |a spatial context |2 Other |
| 650 | _ | 7 | |a spatial transcriptomics |2 Other |
| 650 | _ | 7 | |a tumor immune evasion |2 Other |
| 650 | _ | 7 | |a tumor microenvironment |2 Other |
| 700 | 1 | _ | |a Baertsch, Marc-A |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Reticker-Flynn, Nathan E |b 2 |
| 700 | 1 | _ | |a Lu, Guolan |b 3 |
| 700 | 1 | _ | |a Kempchen, Tim Noah |0 P:(DE-He78)4d263f43f1c0e1d474fb278e8f3c73ca |b 4 |
| 700 | 1 | _ | |a Chu, Pauline |b 5 |
| 700 | 1 | _ | |a Vazquez, Gustavo |b 6 |
| 700 | 1 | _ | |a Chen, Han |b 7 |
| 700 | 1 | _ | |a Sunwoo, John B |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Zhang, Weiruo |b 9 |
| 700 | 1 | _ | |a Laseinde, Eyiwunmi |b 10 |
| 700 | 1 | _ | |a Adami, Bonny |b 11 |
| 700 | 1 | _ | |a Zimmer, Stefanie |b 12 |
| 700 | 1 | _ | |a Kaufman, Justus |b 13 |
| 700 | 1 | _ | |a Le, Quynh Thu |b 14 |
| 700 | 1 | _ | |a Gentles, Andrew J |b 15 |
| 700 | 1 | _ | |a Kong, Christina S |b 16 |
| 700 | 1 | _ | |a Plevritis, Sylvia K |b 17 |
| 700 | 1 | _ | |a Goltsev, Yury |b 18 |
| 700 | 1 | _ | |a Hickey, John W |b 19 |
| 700 | 1 | _ | |a Nolan, Garry P |b 20 |
| 773 | _ | _ | |a 10.1016/j.ccell.2026.01.003 |g p. S1535610826000425 |0 PERI:(DE-600)2074034-7 |p nn |t Cancer cell |v nn |y 2026 |x 1535-6108 |
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