%0 Journal Article
%A Weller, Jonathan
%A Harba, Dima
%A Kuschel, Luis
%A Thiele, Frederic
%A Katzendobler, Sophie
%A Corell, Alba
%A Dénes, Anna
%A Schmutzer-Sondergeld, Michael
%A de Dios, Eddie
%A Ringel, Florian
%A Tonn, Joerg Christian
%A Jakola, Asgeir S
%T Association of a diffuse phenotype on MRI with shorter overall survival in patients with astrocytoma CNS WHO grades 2 and 3.
%J Journal of neurosurgery
%V nn
%@ 0022-3085
%C Charlottesville, Va.
%I American Assoc. of Neurological Surgeons
%M DKFZ-2026-00257
%P nn
%D 2026
%Z #DKTKZFB9# / epub
%X Gliomas can appear radiologically diffuse or sharply delineated on MRI. This can be quantified by the T1/T2 ratio, a quotient of the T1 hypointense to T2 hyperintense tumor volume. In patients with CNS WHO grade 2 and 3 isocitrate dehydrogenase (IDH)-mutant astrocytomas, resectability has been shown to be limited in cases of low T1/T2 ratios, that is, in diffusely appearing astrocytomas. The authors set out to investigate if a diffuse phenotype on MRI is associated with overall survival beyond resectability.Retrospective data sets from two university hospitals (Sahlgrenska University Hospital, Gothenburg, Sweden; LMU University Hospital, Munich, Germany) were screened for patients diagnosed with 2021 CNS WHO grade 2 and 3 astrocytomas by biopsy between 2003 and 2021. Patients having undergone tumor resection were excluded. Tumor volumes were segmented and the T1/T2 ratio was calculated. Propensity score matching (nearest-neighbor matching, 1:1) was used.One hundred nineteen patients with CNS WHO grade 2 (n = 77, 65
%K IDH mutation (Other)
%K biopsy (Other)
%K diagnostic technique (Other)
%K low-grade glioma (Other)
%K oncology (Other)
%K prognosis (Other)
%K risk factor (Other)
%K tumor volume (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41616295
%R 10.3171/2025.9.JNS251254
%U https://inrepo02.dkfz.de/record/309607