TY  - JOUR
AU  - Weller, Jonathan
AU  - Harba, Dima
AU  - Kuschel, Luis
AU  - Thiele, Frederic
AU  - Katzendobler, Sophie
AU  - Corell, Alba
AU  - Dénes, Anna
AU  - Schmutzer-Sondergeld, Michael
AU  - de Dios, Eddie
AU  - Ringel, Florian
AU  - Tonn, Joerg Christian
AU  - Jakola, Asgeir S
TI  - Association of a diffuse phenotype on MRI with shorter overall survival in patients with astrocytoma CNS WHO grades 2 and 3.
JO  - Journal of neurosurgery
VL  - nn
SN  - 0022-3085
CY  - Charlottesville, Va.
PB  - American Assoc. of Neurological Surgeons
M1  - DKFZ-2026-00257
SP  - nn
PY  - 2026
N1  - #DKTKZFB9# / epub
AB  - Gliomas can appear radiologically diffuse or sharply delineated on MRI. This can be quantified by the T1/T2 ratio, a quotient of the T1 hypointense to T2 hyperintense tumor volume. In patients with CNS WHO grade 2 and 3 isocitrate dehydrogenase (IDH)-mutant astrocytomas, resectability has been shown to be limited in cases of low T1/T2 ratios, that is, in diffusely appearing astrocytomas. The authors set out to investigate if a diffuse phenotype on MRI is associated with overall survival beyond resectability.Retrospective data sets from two university hospitals (Sahlgrenska University Hospital, Gothenburg, Sweden; LMU University Hospital, Munich, Germany) were screened for patients diagnosed with 2021 CNS WHO grade 2 and 3 astrocytomas by biopsy between 2003 and 2021. Patients having undergone tumor resection were excluded. Tumor volumes were segmented and the T1/T2 ratio was calculated. Propensity score matching (nearest-neighbor matching, 1:1) was used.One hundred nineteen patients with CNS WHO grade 2 (n = 77, 65
KW  - IDH mutation (Other)
KW  - biopsy (Other)
KW  - diagnostic technique (Other)
KW  - low-grade glioma (Other)
KW  - oncology (Other)
KW  - prognosis (Other)
KW  - risk factor (Other)
KW  - tumor volume (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41616295
DO  - DOI:10.3171/2025.9.JNS251254
UR  - https://inrepo02.dkfz.de/record/309607
ER  -