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@ARTICLE{Kumar:309611,
      author       = {A. Kumar and A. Parveen and F. T. Hansen and J. L.
                      Sørensen and O. R. Bandapalli$^*$ and M. Neerathilingam and
                      K. S. Prasad},
      title        = {{D}eciphering secondary metabolite potentials of halophilic
                      marine-derived {A}spergillus ruber.},
      journal      = {3 Biotech},
      volume       = {16},
      number       = {2},
      issn         = {2190-572X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2026-00261},
      pages        = {84},
      year         = {2026},
      abstract     = {The halophilic marine-derived fungus Aspergillus ruber CBS
                      135680 was systematically investigated for its secondary
                      metabolite potential through genome mining. A total of 36
                      biosynthetic gene clusters (BGCs) were identified, including
                      four non-ribosomal peptide synthetase (NRPS) clusters, eight
                      NRPS-like clusters, eight type I polyketide synthase (T1PKS)
                      clusters, ten terpene clusters, four hybrid clusters, and
                      two siderophore clusters. The largest NRPS cluster (AruBGC2,
                      ~ 58 kb) encodes the siderophore synthase SidC, while
                      AruBGC23 was linked to asperfuranone biosynthesis.
                      Additional clusters were predicted to synthesize bioactive
                      compounds such as cornexistin, TAN-1612, naphthopyrone,
                      clavaric acid, squalestatin S1, asperlactone, and
                      epipyriculol. These metabolites are associated with diverse
                      biological activities, including anticancer, antibacterial,
                      antifungal, nematocidal, and herbicidal properties. The
                      discovery of canonical and noncanonical BGCs pinpoints the
                      metabolic diversity of A. ruber and highlights potential as
                      a promising source of natural products. This study provides
                      the first comprehensive genome-wide assessment of secondary
                      metabolism in A. ruber, offering valuable insights for
                      future drug discovery and biotechnological applications.The
                      online version contains supplementary material available at
                      10.1007/s13205-026-04701-6.},
      keywords     = {Aspergillus ruber CBS 135680 (Other) / Biosynthetic gene
                      clusters (Other) / Halophilic (Other) / Marine-derived
                      genomics (Other)},
      cin          = {C050},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41613168},
      pmc          = {pmc:PMC12847620},
      doi          = {10.1007/s13205-026-04701-6},
      url          = {https://inrepo02.dkfz.de/record/309611},
}