%0 Journal Article
%A Tanavde, Ved
%A Tharakan, Anuj
%A D'Souza, Gypsyamber
%A Hachem, Ralph Abi
%A Windon, Melina J
%A Jung, Sophia
%A Smith, Jordan
%A Alkahtani, Fahad
%A So, Raymond J
%A Jang, David W
%A Queraishi, Tanvir
%A Khan, Zubair
%A Michels, Birgitta
%A Waterboer, Tim
%A Fakhry, Carole
%A London, Nyall R
%T Behavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi-Institutional Case-Control Study.
%J Head & neck
%V nn
%@ 1043-3074
%C New York, NY [u.a.]
%I Wiley Interscience
%M DKFZ-2026-00263
%P nn
%D 2026
%X Sinonasal carcinomas are rare but aggressive malignancies. A subset is associated with high-risk HPV, but risk factors for HPV-associated sinonasal carcinoma (HPV-SNC) and HPV-independent disease remain poorly understood.To evaluate behavioral and clinical risk factors, including sexual history and substance use, and HPV antibody seropositivity in patients with HPV-SNC and HPV-independent SNC.This multi-institutional case-case-control study was conducted from 2021 to 2024 at two NCI-designated cancer centers. Fifty-two patients with sinonasal carcinoma were enrolled; 37 completed a survey of demographic, clinical, and behavioral factors (24 HPV-SNC, 13 HPV-independent SNC) and serology was obtained for 36 (24 HPV-SNC, 12 HPV-independent SNC). Control noncancer otolaryngology patients (n = 148) from a recent prior study were matched 4:1.Self-reported history of sexual behaviors, substance use, and medical history via electronic survey; serum testing for antibodies to low- and high-risk HPV E6, E7, E1, E2, and L1 oncoproteins using a multiplex bead-based assay.Odds of HPV-SNC or HPV-independent SNC diagnosis in relation to risk factors; differences in HPV seropositivity between groups.Among the 37 cancer patients who completed the survey, a history of tonsillectomy was significantly associated with reduced odds of HPV-SNC (OR 0.28, CI 0.09-0.86). No other factors explored (sexual behavior, substance use, or other clinical factors) were associated with HPV-associated SNC and HPV-independent SNC. Seroprevalence of anti-HPV16 E6 was significantly higher among HPV-associated SNC cases than either controls or HPV-independent SNC (45.8
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41609014
%R 10.1002/hed.70171
%U https://inrepo02.dkfz.de/record/309613