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000309613 041__ $$aEnglish
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000309613 1001_ $$aTanavde, Ved$$b0
000309613 245__ $$aBehavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi-Institutional Case-Control Study.
000309613 260__ $$aNew York, NY [u.a.]$$bWiley Interscience$$c2026
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000309613 520__ $$aSinonasal carcinomas are rare but aggressive malignancies. A subset is associated with high-risk HPV, but risk factors for HPV-associated sinonasal carcinoma (HPV-SNC) and HPV-independent disease remain poorly understood.To evaluate behavioral and clinical risk factors, including sexual history and substance use, and HPV antibody seropositivity in patients with HPV-SNC and HPV-independent SNC.This multi-institutional case-case-control study was conducted from 2021 to 2024 at two NCI-designated cancer centers. Fifty-two patients with sinonasal carcinoma were enrolled; 37 completed a survey of demographic, clinical, and behavioral factors (24 HPV-SNC, 13 HPV-independent SNC) and serology was obtained for 36 (24 HPV-SNC, 12 HPV-independent SNC). Control noncancer otolaryngology patients (n = 148) from a recent prior study were matched 4:1.Self-reported history of sexual behaviors, substance use, and medical history via electronic survey; serum testing for antibodies to low- and high-risk HPV E6, E7, E1, E2, and L1 oncoproteins using a multiplex bead-based assay.Odds of HPV-SNC or HPV-independent SNC diagnosis in relation to risk factors; differences in HPV seropositivity between groups.Among the 37 cancer patients who completed the survey, a history of tonsillectomy was significantly associated with reduced odds of HPV-SNC (OR 0.28, CI 0.09-0.86). No other factors explored (sexual behavior, substance use, or other clinical factors) were associated with HPV-associated SNC and HPV-independent SNC. Seroprevalence of anti-HPV16 E6 was significantly higher among HPV-associated SNC cases than either controls or HPV-independent SNC (45.8% vs. 0% and 13.1%), HPV-16 E6 (18.2% vs. 0% and 4.0%), and HPV-16 early proteins (16.7% vs. 0% and 0%) than HPV-independent SNC patients or controls, respectively.HPV-SNC exhibits distinct serologic features without clear behavioral risk factors. The protective association of tonsillectomy suggests lymphoid tissue may play a role in HPV-associated sinonasal oncogenesis. In contrast, the absence of identifiable risk factors for HPV-independent SNC highlights the need for further etiologic studies.
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000309613 7001_ $$00000-0001-8795-1009$$aTharakan, Anuj$$b1
000309613 7001_ $$aD'Souza, Gypsyamber$$b2
000309613 7001_ $$aHachem, Ralph Abi$$b3
000309613 7001_ $$aWindon, Melina J$$b4
000309613 7001_ $$aJung, Sophia$$b5
000309613 7001_ $$aSmith, Jordan$$b6
000309613 7001_ $$aAlkahtani, Fahad$$b7
000309613 7001_ $$aSo, Raymond J$$b8
000309613 7001_ $$aJang, David W$$b9
000309613 7001_ $$aQueraishi, Tanvir$$b10
000309613 7001_ $$aKhan, Zubair$$b11
000309613 7001_ $$0P:(DE-He78)b48bfd64120195b64b5f11d32ce5ed5e$$aMichels, Birgitta$$b12$$udkfz
000309613 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, Tim$$b13$$udkfz
000309613 7001_ $$aFakhry, Carole$$b14
000309613 7001_ $$00000-0002-2902-4407$$aLondon, Nyall R$$b15
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