TY  - JOUR
AU  - Tanavde, Ved
AU  - Tharakan, Anuj
AU  - D'Souza, Gypsyamber
AU  - Hachem, Ralph Abi
AU  - Windon, Melina J
AU  - Jung, Sophia
AU  - Smith, Jordan
AU  - Alkahtani, Fahad
AU  - So, Raymond J
AU  - Jang, David W
AU  - Queraishi, Tanvir
AU  - Khan, Zubair
AU  - Michels, Birgitta
AU  - Waterboer, Tim
AU  - Fakhry, Carole
AU  - London, Nyall R
TI  - Behavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi-Institutional Case-Control Study.
JO  - Head & neck
VL  - nn
SN  - 1043-3074
CY  - New York, NY [u.a.]
PB  - Wiley Interscience
M1  - DKFZ-2026-00263
SP  - nn
PY  - 2026
AB  - Sinonasal carcinomas are rare but aggressive malignancies. A subset is associated with high-risk HPV, but risk factors for HPV-associated sinonasal carcinoma (HPV-SNC) and HPV-independent disease remain poorly understood.To evaluate behavioral and clinical risk factors, including sexual history and substance use, and HPV antibody seropositivity in patients with HPV-SNC and HPV-independent SNC.This multi-institutional case-case-control study was conducted from 2021 to 2024 at two NCI-designated cancer centers. Fifty-two patients with sinonasal carcinoma were enrolled; 37 completed a survey of demographic, clinical, and behavioral factors (24 HPV-SNC, 13 HPV-independent SNC) and serology was obtained for 36 (24 HPV-SNC, 12 HPV-independent SNC). Control noncancer otolaryngology patients (n = 148) from a recent prior study were matched 4:1.Self-reported history of sexual behaviors, substance use, and medical history via electronic survey; serum testing for antibodies to low- and high-risk HPV E6, E7, E1, E2, and L1 oncoproteins using a multiplex bead-based assay.Odds of HPV-SNC or HPV-independent SNC diagnosis in relation to risk factors; differences in HPV seropositivity between groups.Among the 37 cancer patients who completed the survey, a history of tonsillectomy was significantly associated with reduced odds of HPV-SNC (OR 0.28, CI 0.09-0.86). No other factors explored (sexual behavior, substance use, or other clinical factors) were associated with HPV-associated SNC and HPV-independent SNC. Seroprevalence of anti-HPV16 E6 was significantly higher among HPV-associated SNC cases than either controls or HPV-independent SNC (45.8
LB  - PUB:(DE-HGF)16
C6  - pmid:41609014
DO  - DOI:10.1002/hed.70171
UR  - https://inrepo02.dkfz.de/record/309613
ER  -