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@ARTICLE{Tanavde:309613,
      author       = {V. Tanavde and A. Tharakan and G. D'Souza and R. A. Hachem
                      and M. J. Windon and S. Jung and J. Smith and F. Alkahtani
                      and R. J. So and D. W. Jang and T. Queraishi and Z. Khan and
                      B. Michels$^*$ and T. Waterboer$^*$ and C. Fakhry and N. R.
                      London},
      title        = {{B}ehavioral {R}isk {F}actors and {S}eroprevalence for
                      {H}uman {P}apillomavirus in {S}inonasal {C}arcinoma: {A}
                      {M}ulti-{I}nstitutional {C}ase-{C}ontrol {S}tudy.},
      journal      = {Head $\&$ neck},
      volume       = {nn},
      issn         = {1043-3074},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley Interscience},
      reportid     = {DKFZ-2026-00263},
      pages        = {nn},
      year         = {2026},
      abstract     = {Sinonasal carcinomas are rare but aggressive malignancies.
                      A subset is associated with high-risk HPV, but risk factors
                      for HPV-associated sinonasal carcinoma (HPV-SNC) and
                      HPV-independent disease remain poorly understood.To evaluate
                      behavioral and clinical risk factors, including sexual
                      history and substance use, and HPV antibody seropositivity
                      in patients with HPV-SNC and HPV-independent SNC.This
                      multi-institutional case-case-control study was conducted
                      from 2021 to 2024 at two NCI-designated cancer centers.
                      Fifty-two patients with sinonasal carcinoma were enrolled;
                      37 completed a survey of demographic, clinical, and
                      behavioral factors (24 HPV-SNC, 13 HPV-independent SNC) and
                      serology was obtained for 36 (24 HPV-SNC, 12 HPV-independent
                      SNC). Control noncancer otolaryngology patients (n = 148)
                      from a recent prior study were matched 4:1.Self-reported
                      history of sexual behaviors, substance use, and medical
                      history via electronic survey; serum testing for antibodies
                      to low- and high-risk HPV E6, E7, E1, E2, and L1
                      oncoproteins using a multiplex bead-based assay.Odds of
                      HPV-SNC or HPV-independent SNC diagnosis in relation to risk
                      factors; differences in HPV seropositivity between
                      groups.Among the 37 cancer patients who completed the
                      survey, a history of tonsillectomy was significantly
                      associated with reduced odds of HPV-SNC (OR 0.28, CI
                      0.09-0.86). No other factors explored (sexual behavior,
                      substance use, or other clinical factors) were associated
                      with HPV-associated SNC and HPV-independent SNC.
                      Seroprevalence of anti-HPV16 E6 was significantly higher
                      among HPV-associated SNC cases than either controls or
                      HPV-independent SNC $(45.8\%$ vs. $0\%$ and $13.1\%),$
                      HPV-16 E6 $(18.2\%$ vs. $0\%$ and $4.0\%),$ and HPV-16 early
                      proteins $(16.7\%$ vs. $0\%$ and $0\%)$ than HPV-independent
                      SNC patients or controls, respectively.HPV-SNC exhibits
                      distinct serologic features without clear behavioral risk
                      factors. The protective association of tonsillectomy
                      suggests lymphoid tissue may play a role in HPV-associated
                      sinonasal oncogenesis. In contrast, the absence of
                      identifiable risk factors for HPV-independent SNC highlights
                      the need for further etiologic studies.},
      cin          = {C230},
      ddc          = {610},
      cid          = {I:(DE-He78)C230-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41609014},
      doi          = {10.1002/hed.70171},
      url          = {https://inrepo02.dkfz.de/record/309613},
}