%0 Journal Article
%A Peoples, Anita R
%A Obón-Santacana, Mireia
%A Kim, Andre E
%A Kawaguchi, Eric S
%A Fu, Yubo
%A Qu, Conghui
%A Moratalla-Navarro, Ferran
%A Morrison, John
%A Lin, Yi
%A Arndt, Volker
%A Berndt, Sonja I
%A Bien, Stephanie A
%A Bishop, D Timothy
%A Bouras, Emmanouil
%A Brenner, Hermann
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Conti, David V
%A Corley, Douglas Ac
%A Devall, Matthew A
%A Dimou, Niki
%A Drew, David A
%A Gruber, Stephen B
%A Gunter, Marc J
%A Harlid, Sophia
%A Harrison, Tabitha A
%A Hoffmeister, Michael
%A Hsu, Li
%A Huyghe, Jeroen R
%A Keku, Temitope O
%A Kundaje, Anshul
%A Lewinger, Juan Pablo
%A Li, Li
%A Lynch, Brigid M
%A Le Marchand, Loic
%A Martín, Vicente
%A Murphy, Neil
%A Newton, Christina C
%A Ogino, Shuji
%A Hardikar, Sheetal
%A Ose, Jennifer
%A Pai, Rish K
%A Palmer, Julie R
%A Papadimitriou, Nikos
%A Pardamean, Bens
%A Pellatt, Andrew J
%A Pinchev, Mila
%A Platz, Elizabeth A
%A Potter, John D
%A Rennert, Gad
%A Ruiz-Narvaez, Edward A
%A Sakoda, Lori C
%A Schoen, Robert E
%A Shcherbina, Anna
%A Stern, Mariana C
%A Su, Yu-Ru
%A Thomas, Claire E
%A Tian, Yu
%A Tsilidis, Konstantinos K
%A Um, Caroline Y
%A van Duijnhoven, Franzel J B
%A Van Guelpen, Bethany
%A Visvanathan, Kala
%A Wang, Jun
%A White, Emily
%A Wolk, Alicja
%A Woods, Michael O
%A Wu, Anna H
%A Ulrich, Cornelia M
%A Peters, Ulrike
%A Gauderman, W James
%A Moreno, Victor
%T Genetic risk factors modulate the association between physical activity and colorectal cancer.
%J BMC medicine
%V nn
%@ 1741-7015
%C London
%I BioMed Central
%M DKFZ-2026-00296
%P nn
%D 2026
%Z #DKTKZFB26# / #NCTZFB26# / epub
%X Physical activity is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene-physical activity interaction analysis.Using logistic regression (1-d.f), two-step screening and testing method (EDGE), and joint tests (3-d.f), we analyzed interactions between common genetic variants across the genome and physical activity in relation to CRC risk. Self-reported physical activity levels were categorized as active (≥ 8.75 MET-h/wk) vs. inactive (< 8.75 MET-h/wk; 39,992 participants) and as study- and sex-specific quartiles of activity (42,602 participants).Physical activity was inversely associated with CRC risk overall (OR [active vs. inactive] = 0.85; 95
%K Colorectal cancer (Other)
%K GWAS (Other)
%K Gene-environment interaction (Other)
%K Physical activity (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41645200
%R 10.1186/s12916-026-04675-5
%U https://inrepo02.dkfz.de/record/309674