TY  - JOUR
AU  - Mecklenbrauck, Rabea
AU  - Villaverde Ramiro, Angela
AU  - Sträng, Eric
AU  - Gabdoulline, Razif
AU  - Martinez Elicegui, Javier
AU  - Sobas, Marta
AU  - Pleyer, Lisa
AU  - Turki, Amin
AU  - Voso, Maria Teresa
AU  - Benner, Axel
AU  - Hernández-Sánchez, Alberto
AU  - Tettero, Jesse M
AU  - Tur Gimenez, Laura
AU  - Metzeler, Klaus H
AU  - Oñate, Guadalupe
AU  - Lehmann, Sören
AU  - Huntly, Brian Jp
AU  - Thomas, Ian
AU  - Thol, Felicitas R
AU  - Heidel, Florian H
AU  - Valk, Peter Jm
AU  - Döhner, Konstanze
AU  - Haferlach, Torsten
AU  - Mills, Kenneth I
AU  - Döhner, Hartmut
AU  - Castellani, Gastone
AU  - Ossenkoppele, Gert J
AU  - Hernández-Rivas, Jesus María
AU  - Bullinger, Lars
AU  - Heuser, Michael
TI  - Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia.
JO  - Leukemia
VL  - nn
SN  - 0887-6924
CY  - London
PB  - Springer Nature
M1  - DKFZ-2026-00316
SP  - nn
PY  - 2026
N1  - epub
AB  - The inclusion of nine myelodysplasia-related gene (MRG) mutations (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, ZRSR2) as adverse risk factors in the ELN risk classification has reshaped classification in acute myeloid leukemia (AML). AML with FLT3-ITD mutations and co-occurring MRG alterations is now classified to the ELN adverse risk group although supporting evidence remains limited. Among 4,078 patients with AML with available molecular information included in the HARMONY platform, 862 harbored FLT3-ITD mutations and underwent intensive chemotherapy. Of these, 171 (20
LB  - PUB:(DE-HGF)16
C6  - pmid:41663622
DO  - DOI:10.1038/s41375-026-02874-w
UR  - https://inrepo02.dkfz.de/record/309803
ER  -