%0 Journal Article
%A Mirian, Christian
%A Jensen, Lasse Rehné
%A Hoffmann, Adam Gorm
%A Juratli, Tareq A
%A Maier, Andrea Daniela
%A Lindner, Pernilla
%A Broechner, Anders
%A Torp, Sverre H
%A Shih, Helen A
%A Morshed, Ramin A
%A Young, Jacob S
%A Magill, Stephen T
%A Stummer, Walter
%A Spille, Dorothee Cäcilia
%A Brokinkel, Benjamin
%A Proescholdt, Martin
%A Kuroi, Yasuhiro
%A Gousias, Konstantinos
%A Simon, Matthias
%A Prat-Acin, Ricardo
%A Goutagny, Stéphane
%A Wach, Johannes
%A Güresir, Erdem
%A Yamamoto, Junkoh
%A Kim, Young Zoon
%A Lee, Joo Ho
%A Kim, Daniel W
%A Koshy, Matthew
%A Cannon, Donald M
%A Shrieve, Dennis C
%A Suh, Chang-Ok
%A Chang, Jong Hee
%A Kamenova, Maria
%A Straumann, Sven
%A Soleman, Jehuda
%A Eyüpoglu, Ilker Y
%A Catalan, Tony
%A Lui, Austin
%A Theodosopoulos, Philip V
%A McDermott, Michael W
%A Góes, Pedro
%A Wang, Fang
%A Souhami, Luis
%A Guiot, Marie-Christine
%A Csonka, Tamás
%A Endo, Toshiki
%A Gupta, Tejpal
%A Patel, Akash J
%A Klisch, Tiemo J
%A Kim, Jun Won
%A Maiuri, Francesco
%A Barresi, Valeria
%A Tabernero, María Dolores
%A Skyrman, Simon
%A Krause, Mechthild
%A Law, Ian
%A Kristensen, Bjarne Winther
%A Munch, Tina Nørgaard
%A Meling, Torstein
%A Fugleholm, Kåre
%A Blanche, Paul
%A Mathiesen, Tiit
%T Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.
%J Journal of neuro-oncology
%V 176
%N 3
%@ 0167-594X
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V
%M DKFZ-2026-00319
%P 201
%D 2026
%Z #DKTKZFB26# / #NCTZFB26#
%X Purpose:The role of adjuvant fractionated radiotherapy (aFRT) after gross total resection (GTR) of WHO-2 meningiomas remains unclear. We aimed to estimate the effect of aFRT on recurrence risk and survival following GTR and subtotal resection (STR).Methods:We analyzed 1452 patients with WHO-2 from our international, multicenter database (followed between 1989 and 2019). Outcomes were recurrence (10-year follow-up) and death (5-year follow-up). Risk estimates were obtained using competing risks and survival analysis. Average treatment effects were estimated by G-computation, adjusted for potential confounding by age, sex, Simpson grade, Ki-67 proliferation index, location, country group (universal healthcare or not), and year of treatment initiation. The robustness of findings was examined through sensitivity analyses.Results:Overall, 276 of 1452 patients (19.0
%K Atypical meningioma (Other)
%K Meningioma (Other)
%K Progression (Other)
%K Radiotherapy (Other)
%K Recurrence (Other)
%K Resection (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41661453
%R 10.1007/s11060-025-05349-7
%U https://inrepo02.dkfz.de/record/309806