TY  - JOUR
AU  - Mirian, Christian
AU  - Jensen, Lasse Rehné
AU  - Hoffmann, Adam Gorm
AU  - Juratli, Tareq A
AU  - Maier, Andrea Daniela
AU  - Lindner, Pernilla
AU  - Broechner, Anders
AU  - Torp, Sverre H
AU  - Shih, Helen A
AU  - Morshed, Ramin A
AU  - Young, Jacob S
AU  - Magill, Stephen T
AU  - Stummer, Walter
AU  - Spille, Dorothee Cäcilia
AU  - Brokinkel, Benjamin
AU  - Proescholdt, Martin
AU  - Kuroi, Yasuhiro
AU  - Gousias, Konstantinos
AU  - Simon, Matthias
AU  - Prat-Acin, Ricardo
AU  - Goutagny, Stéphane
AU  - Wach, Johannes
AU  - Güresir, Erdem
AU  - Yamamoto, Junkoh
AU  - Kim, Young Zoon
AU  - Lee, Joo Ho
AU  - Kim, Daniel W
AU  - Koshy, Matthew
AU  - Cannon, Donald M
AU  - Shrieve, Dennis C
AU  - Suh, Chang-Ok
AU  - Chang, Jong Hee
AU  - Kamenova, Maria
AU  - Straumann, Sven
AU  - Soleman, Jehuda
AU  - Eyüpoglu, Ilker Y
AU  - Catalan, Tony
AU  - Lui, Austin
AU  - Theodosopoulos, Philip V
AU  - McDermott, Michael W
AU  - Góes, Pedro
AU  - Wang, Fang
AU  - Souhami, Luis
AU  - Guiot, Marie-Christine
AU  - Csonka, Tamás
AU  - Endo, Toshiki
AU  - Gupta, Tejpal
AU  - Patel, Akash J
AU  - Klisch, Tiemo J
AU  - Kim, Jun Won
AU  - Maiuri, Francesco
AU  - Barresi, Valeria
AU  - Tabernero, María Dolores
AU  - Skyrman, Simon
AU  - Krause, Mechthild
AU  - Law, Ian
AU  - Kristensen, Bjarne Winther
AU  - Munch, Tina Nørgaard
AU  - Meling, Torstein
AU  - Fugleholm, Kåre
AU  - Blanche, Paul
AU  - Mathiesen, Tiit
TI  - Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.
JO  - Journal of neuro-oncology
VL  - 176
IS  - 3
SN  - 0167-594X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DKFZ-2026-00319
SP  - 201
PY  - 2026
N1  - #DKTKZFB26# / #NCTZFB26#
AB  - Purpose:The role of adjuvant fractionated radiotherapy (aFRT) after gross total resection (GTR) of WHO-2 meningiomas remains unclear. We aimed to estimate the effect of aFRT on recurrence risk and survival following GTR and subtotal resection (STR).Methods:We analyzed 1452 patients with WHO-2 from our international, multicenter database (followed between 1989 and 2019). Outcomes were recurrence (10-year follow-up) and death (5-year follow-up). Risk estimates were obtained using competing risks and survival analysis. Average treatment effects were estimated by G-computation, adjusted for potential confounding by age, sex, Simpson grade, Ki-67 proliferation index, location, country group (universal healthcare or not), and year of treatment initiation. The robustness of findings was examined through sensitivity analyses.Results:Overall, 276 of 1452 patients (19.0
KW  - Atypical meningioma (Other)
KW  - Meningioma (Other)
KW  - Progression (Other)
KW  - Radiotherapy (Other)
KW  - Recurrence (Other)
KW  - Resection (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41661453
DO  - DOI:10.1007/s11060-025-05349-7
UR  - https://inrepo02.dkfz.de/record/309806
ER  -