%0 Journal Article
%A Behr, Luise Charlotte
%A Kluttig, Alexander
%A Simm, Andreas
%A Mikolajczyk, Rafael
%A Kraus, Frank Bernhard
%A Sedding, Daniel
%A Greiser, Karin Halina
%A Wienke, Andreas
%A Großkopf, Anne
%T Are levels of DHEAS indicative of subjective health - results of the population-based longitudinal CARLA study.
%J npj aging
%V nn
%@ 2056-3973
%C [London]
%I Springer Nature
%M DKFZ-2026-00405
%P nn
%D 2026
%Z epub
%X Subjective and objective markers are important in describing healthy aging, yet little is known about their relationships. This study analysed the time-dependent association of dehydroepiandrosterone sulfate (DHEAS) with subjective health. At baseline, DHEAS was measured in participants aged 45-83 randomly selected from the general population. Subjective mental and physical health were assessed using the 12-item Short Form (SF-12) questionnaire at baseline and two follow-ups. In sex-specific linear regression models controlled for age, weight, tobacco consumption, Charlson Comorbidity Index, depression, and testosterone levels, the associations of DHEAS with the subscores of the SF-12 were analysed. DHEAS showed a positive cross-sectional association with subjective physical health, which was stronger in women and remained relevant after multivariable adjustment. However, longitudinal analyses revealed no long-term effect of DHEAS on subjective health. These findings suggest that the association between DHEAS and subjective physical health is temporary and that an underlying causality is unlikely.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41714619
%R 10.1038/s41514-026-00346-0
%U https://inrepo02.dkfz.de/record/309979