TY  - JOUR
AU  - Behr, Luise Charlotte
AU  - Kluttig, Alexander
AU  - Simm, Andreas
AU  - Mikolajczyk, Rafael
AU  - Kraus, Frank Bernhard
AU  - Sedding, Daniel
AU  - Greiser, Karin Halina
AU  - Wienke, Andreas
AU  - Großkopf, Anne
TI  - Are levels of DHEAS indicative of subjective health - results of the population-based longitudinal CARLA study.
JO  - npj aging
VL  - nn
SN  - 2056-3973
CY  - [London]
PB  - Springer Nature
M1  - DKFZ-2026-00405
SP  - nn
PY  - 2026
N1  - epub
AB  - Subjective and objective markers are important in describing healthy aging, yet little is known about their relationships. This study analysed the time-dependent association of dehydroepiandrosterone sulfate (DHEAS) with subjective health. At baseline, DHEAS was measured in participants aged 45-83 randomly selected from the general population. Subjective mental and physical health were assessed using the 12-item Short Form (SF-12) questionnaire at baseline and two follow-ups. In sex-specific linear regression models controlled for age, weight, tobacco consumption, Charlson Comorbidity Index, depression, and testosterone levels, the associations of DHEAS with the subscores of the SF-12 were analysed. DHEAS showed a positive cross-sectional association with subjective physical health, which was stronger in women and remained relevant after multivariable adjustment. However, longitudinal analyses revealed no long-term effect of DHEAS on subjective health. These findings suggest that the association between DHEAS and subjective physical health is temporary and that an underlying causality is unlikely.
LB  - PUB:(DE-HGF)16
C6  - pmid:41714619
DO  - DOI:10.1038/s41514-026-00346-0
UR  - https://inrepo02.dkfz.de/record/309979
ER  -