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@ARTICLE{Behr:309979,
      author       = {L. C. Behr and A. Kluttig and A. Simm and R. Mikolajczyk
                      and F. B. Kraus and D. Sedding and K. H. Greiser$^*$ and A.
                      Wienke and A. Großkopf},
      title        = {{A}re levels of {DHEAS} indicative of subjective health -
                      results of the population-based longitudinal {CARLA} study.},
      journal      = {npj aging},
      volume       = {nn},
      issn         = {2056-3973},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2026-00405},
      pages        = {nn},
      year         = {2026},
      note         = {epub},
      abstract     = {Subjective and objective markers are important in
                      describing healthy aging, yet little is known about their
                      relationships. This study analysed the time-dependent
                      association of dehydroepiandrosterone sulfate (DHEAS) with
                      subjective health. At baseline, DHEAS was measured in
                      participants aged 45-83 randomly selected from the general
                      population. Subjective mental and physical health were
                      assessed using the 12-item Short Form (SF-12) questionnaire
                      at baseline and two follow-ups. In sex-specific linear
                      regression models controlled for age, weight, tobacco
                      consumption, Charlson Comorbidity Index, depression, and
                      testosterone levels, the associations of DHEAS with the
                      subscores of the SF-12 were analysed. DHEAS showed a
                      positive cross-sectional association with subjective
                      physical health, which was stronger in women and remained
                      relevant after multivariable adjustment. However,
                      longitudinal analyses revealed no long-term effect of DHEAS
                      on subjective health. These findings suggest that the
                      association between DHEAS and subjective physical health is
                      temporary and that an underlying causality is unlikely.},
      cin          = {C020},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41714619},
      doi          = {10.1038/s41514-026-00346-0},
      url          = {https://inrepo02.dkfz.de/record/309979},
}