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@ARTICLE{Zitricky:310133,
      author       = {F. Zitricky and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and A. Hemminki and R. Kaaks$^*$ and K.
                      Hemminki$^*$},
      title        = {{I}ncrease in second primary lung cancers in a nation-wide
                      cohort study from {S}weden.},
      journal      = {Thorax},
      volume       = {nn},
      issn         = {0040-6376},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DKFZ-2026-00461},
      pages        = {nn},
      year         = {2026},
      note         = {#LA:Z999# / epub},
      abstract     = {We describe the occurrence of second primary lung cancers
                      (SPLCs) and their determinant in Sweden.Nation-wide cancer
                      registry from years 1961 to 2021 identified a total of 853
                      SPLCs.The incidence of SPLCs increased almost linearly from
                      1980 onwards, equally for women and men and approximately
                      equally after the four main histological types. SPLC
                      included adenocarcinoma $63.9\%,$ squamous cell carcinoma
                      (SCC) $19.4\%,$ small cell carcinoma $9.6\%$ and large cell
                      carcinoma $9.1\%.$ The female cumulative probability (CumP)
                      of SPLC after first adenocarcinoma in 10 years reached
                      0.019, after SCC 0.015 and after small and large cell
                      carcinoma 0.008. The respective CumP for men was 0.013,
                      0.012, 0.002 and 0.005. While adenocarcinoma was often
                      followed by second adenocarcinoma, after first
                      non-adenocarcinoma SPLCs presented in diverse histologies.
                      Relative risk of SPLC compared with first lung cancer was
                      overall 3.59, higher for women (4.16) than for men (2.99)
                      and approximately equally high after adenocarcinoma and SCC.
                      In patients diagnosed before age 55 years, the relative risk
                      was 6.68 for all, but after female adenocarcinoma it was
                      9.95 compared with 6.77 for males. The highest relative
                      risks, up to 20-fold, were found after early onset female
                      adenocarcinoma diagnosed after defined T stages.Although
                      SPLCs are still rare, their number is increasing rapidly and
                      the relative risks compared with first lung cancer are
                      substantial, qualifying selected groups of high-risk
                      patients, such as patients with early onset adenocarcinoma
                      for early detection by CT screening when/if such tests
                      become available.},
      keywords     = {Histology/Cytology (Other) / Lung Cancer (Other) / Rare
                      lung diseases (Other)},
      cin          = {B062 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41748422},
      doi          = {10.1136/thorax-2025-223426},
      url          = {https://inrepo02.dkfz.de/record/310133},
}