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@ARTICLE{Kiermeier:310298,
      author       = {S. Kiermeier and C. Sauer and M. Helaß and J. Nees and M.
                      Keymling$^*$ and F. Silchmüller and C. M. Dutzmann and C.
                      P. Kratz and S. Schott and I. Maatouk},
      title        = {{A} brief feasibility report on an online psychosocial
                      support intervention for adults with {L}i-{F}raumeni
                      syndrome.},
      journal      = {Frontiers in psychology},
      volume       = {16},
      issn         = {1664-1078},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DKFZ-2026-00521},
      pages        = {1688050},
      year         = {2026},
      abstract     = {Li-Fraumeni syndrome (LFS) is a rare autosomal dominant
                      cancer predisposition syndrome characterized by a markedly
                      elevated lifetime cancer risk. Despite the substantial
                      psychological burden associated with LFS, tailored
                      psychosocial interventions remain unavailable. Acceptance
                      and commitment therapy (ACT) and cognitive behavioral
                      therapy (CBT) are evidence-based approaches widely applied
                      in psycho-oncological care; however, no intervention has
                      been specifically adapted for individuals with LFS.
                      Consequently, we developed OnLiFe, an online self-management
                      program designed to meet the unique needs of this population
                      and investigated its acceptability and practicality in a
                      small adult cohort.OnLiFe comprises six modules focusing on
                      psychoeducation about emotions, mindfulness practices, and
                      resource activation. Acceptability and practicality were
                      assessed in terms of comprehension and satisfaction with
                      content, usefulness, simplicity, and integrability for each
                      module and content element. Qualitative feedback was
                      collected through open-ended questions and analyzed using
                      qualitative content analysis.Nine female participants (mean
                      age 46.0 ± 7.1 years) enrolled, of whom four completed all
                      modules. Participant satisfaction with OnLiFe was rated
                      moderate to high, while perceived helpfulness of the content
                      showed relatively lower ratings. Qualitative data indicated
                      that the intervention was perceived as too lengthy and that
                      participants' busy schedules limited full engagement.Given
                      the distinct challenges of LFS, tailored psychosocial
                      support is required. Despite careful theoretical
                      considerations, OnLiFe showed mixed results regarding
                      acceptability and practicality. Addressing time constraints
                      will be essential, and future studies are warranted to
                      optimize and determine the efficacy of an adapted version of
                      OnLiFe.},
      keywords     = {Li–Fraumeni syndrome (Other) / cancer (Other) / cancer
                      predisposition syndrome (Other) / eHealth (Other) /
                      psychooncology (Other)},
      cin          = {E010},
      ddc          = {150},
      cid          = {I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41778070},
      pmc          = {pmc:PMC12951781},
      doi          = {10.3389/fpsyg.2025.1688050},
      url          = {https://inrepo02.dkfz.de/record/310298},
}