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@ARTICLE{Yin:310347,
      author       = {Q. Yin$^*$ and J. Stevenson-Hoare$^*$ and B. Holleczek and
                      B. Schöttker$^*$ and H. Brenner$^*$},
      title        = {{E}pigenetic aging and cancer incidence in a {G}erman
                      cohort of older adults.},
      journal      = {npj aging},
      volume       = {nn},
      issn         = {2056-3973},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2026-00547},
      pages        = {nn},
      year         = {2026},
      note         = {#EA:C070#LA:M320# / epub},
      abstract     = {Rising life expectancy and an aging population highlight
                      the importance of cancer control. DNA methylation
                      (DNAm)-based biological age (BA) may provide insights into
                      aging, carcinogenesis, and cancer prevention and care. We
                      estimated five BA metrics among 1916 participants aged 50-75
                      years at baseline in the German ESTHER cohort, with repeat
                      BA measurements available for 894 participants after 8
                      years. Multivariable linear regression was used to assess
                      associations between prior cancer and baseline BA, while Cox
                      proportional hazards models and restricted cubic splines
                      evaluated associations of BA levels and trajectories with
                      subsequent cancer risk. A history of malignant tumors was
                      associated with higher baseline PCHannum and PCGrimAge in
                      fully adjusted models. Older BA levels were significantly
                      associated with increased long-term cancer risk, with hazard
                      ratios up to 1.67 $(95\%$ CI 1.25-2.24) per standard
                      deviation (SD) increase in PCGrimAge. Except for PCGrimAge,
                      BA trajectories showed monotonic, linear associations with
                      cancer risk, corresponding to a $33\%$ to $37\%$ higher risk
                      per SD increase in slopes of four BA matrices. Accelerated
                      biological aging was consistently associated with increased
                      overall cancer risk, highlighting the potential value of
                      longitudinal BA measures for cancer risk assessment,
                      prevention, and monitoring.},
      cin          = {C070 / M320},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)M320-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41803162},
      doi          = {10.1038/s41514-026-00356-y},
      url          = {https://inrepo02.dkfz.de/record/310347},
}