Vita Publications

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2024-01-11
15:31
[DKFZ-2024-00104] Journal Article
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Synaptogenesis in the cerebellar cortex: differential regulation of gephyrin and GABAA receptors at somatic and dendritic synapses of Purkinje cells.
In rodent cerebellar cortex, synaptogenesis occurs entirely postnatally, allowing study of the mechanisms of synapse formation in vivo. Here we monitored the clustering of GABA(A) receptors and the scaffolding protein gephyrin at GABAergic postsynaptic sites during rat cerebellar development. [...]

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2024-01-11
15:30
DBCoverage [DKFZ-2024-00103] Journal Article
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Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex.
PLOS ONE 5(8), e12119 () [10.1371/journal.pone.0012119]  GO
In the cerebellar cortex, interneurons of the molecular layer (stellate and basket cells) provide GABAergic input to Purkinje cells, as well as to each other and possibly to other interneurons. GABAergic inhibition in the molecular layer has mainly been investigated at the interneuron to Purkinje cell synapse. [...]

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2024-01-11
15:29
pmc [DKFZ-2024-00102] Journal Article
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Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors.
GABAergic synapses are crucial for brain function, but the mechanisms underlying inhibitory synaptogenesis are unclear. Here, we show that postnatal Purkinje cells (PCs) of GABA(A)alpha1 knockout (KO) mice express transiently the alpha3 subunit, leading to the assembly of functional GABA(A) receptors and initial normal formation of inhibitory synapses, that are retained until adulthood. [...]

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2024-01-11
15:28
[DKFZ-2024-00101] Journal Article
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Selective localization of collybistin at a subset of inhibitory synapses in brain circuits.
Collybistin is a brain-specific guanine nucleotide exchange factor (GEF) that is crucial for the postsynaptic accumulation of gephyrin and γ-aminobutyric acid A receptors (GABA(A) Rs) at a specific subset of inhibitory synapses. Our understanding of the in vivo function of collybistin has been hampered by lack of information about the synaptic localization of this protein in brain circuits. [...]

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2024-01-11
15:27
pmc [DKFZ-2024-00100] Journal Article
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Complex role of collybistin and gephyrin in GABAA receptor clustering.
Gephyrin and collybistin are key components of GABA(A) receptor (GABA(A)R) clustering. Nonetheless, resolving the molecular interactions between the plethora of GABA(A)R subunits and these clustering proteins is a significant challenge. [...]

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2024-01-11
15:26
pmc [DKFZ-2024-00099] Journal Article
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Synaptic competition sculpts the development of GABAergic axo-dendritic but not perisomatic synapses.
PLOS ONE 8(2), e56311 () [10.1371/journal.pone.0056311]  GO
The neurotransmitter GABA regulates many aspects of inhibitory synapse development. We tested the hypothesis that GABAA receptors (GABAARs) work together with the synaptic adhesion molecule neuroligin 2 (NL2) to regulate synapse formation in different subcellular compartments. [...]

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2024-01-11
15:25
pmc [DKFZ-2024-00098] Journal Article
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NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.
Neuron 76(6), 1078 - 1090 () [10.1016/j.neuron.2012.12.004]  GO
Brain function is shaped by postnatal experience and vulnerable to disruption of Methyl-CpG-binding protein, Mecp2, in multiple neurodevelopmental disorders. How Mecp2 contributes to the experience-dependent refinement of specific cortical circuits and their impairment remains unknown. [...]

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2024-01-11
15:24
pmc [DKFZ-2024-00097] Journal Article
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Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Neuroligins (NL1-NL4) are postsynaptic adhesion proteins that control the maturation and function of synapses in the central nervous system (CNS). Loss-of-function mutations in NL4 are linked to rare forms of monogenic heritable autism, but its localization and function are unknown. [...]

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2024-01-11
15:23
pmc [DKFZ-2024-00096] Journal Article
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CAGE-defined promoter regions of the genes implicated in Rett Syndrome.
Mutations in three functionally diverse genes cause Rett Syndrome. Although the functions of Forkhead box G1 (FOXG1), Methyl CpG binding protein 2 (MECP2) and Cyclin-dependent kinase-like 5 (CDKL5) have been studied individually, not much is known about their relation to each other with respect to expression levels and regulatory regions. [...]

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2024-01-11
15:22
pmc [DKFZ-2024-00095] Journal Article
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Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype.
Rett syndrome (RTT) is a neurological disorder caused by mutation of the X-linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory neuronal circuits. To date, there is no effective treatment available for the disorder. [...]

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