Open Access

Brain metastases (BM) from non-small cell lung cancer (NSCLC) are a relevant cause of morbidity and mortality. This study aims to identify a population at high risk for BM in order to inform personalized follow-up strategies in the future. [...]

Non-functional pancreatic neuroendocrine tumors (NF-pNETs) are increasingly diagnosed, particularly in older adults, largely due to widespread cross-sectional imaging. Patients with NF-pNETs typically have a soft pancreas and a small main pancreatic duct, which puts them at high risk for postoperative pancreatic fistula B/C, significantly impacting postoperative morbidity and mortality. [...]

MicroRNAs (miRNAs) are key regulators of gene expression in both health and disease. Their expression and regulatory functions are highly complex and spatiotemporally organized within tissues. [...]

Purpose:In prostate cancer, Lutetium-177 ([177Lu]Lu )-Prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) shows benefit even in earlier stages of the treatment course, potentially leading to broader application also in younger patients. However, evidence regarding its efficacy and safety in this population remains limited.Methods:Based on Gleason score, baseline prostate specific antigen (PSA) and prior chemotherapy status, 51 patients ≤ 65 years of age were matched to 51 patients ≥ 70 years. [...]

Monitoring MYCN-driven high-risk neuroblastoma presents challenges to capture dynamics of all tumor cell clones at their earliest divergence to current clinical course. Not all clones may enter the bone marrow, the most important monitoring site for minimal residual disease (MRD), causing relapse in ∼50% of patients. [...]

The MORPHEUS platform comprised multiple open-label, randomized, phase Ib/II trials to identify early signals with different treatment combinations across multiple cancers. MORPHEUS-PDAC (NCT03193190) evaluated atezolizumab combinations in pancreatic ductal adenocarcinoma (PDAC). [...]

Tumor cells often cope with elevated levels of replication stress (RS) causing increased dependency on ATR-CHK1 signaling. We previously presented RRM2, the regulatory component of the ribonucleotide reductase (RNR) enzyme, as novel dependency in neuroblastoma (NB), in keeping with its role in RS resistance. [...]

Oncogenes such as KRAS display marked tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved1-5. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities ( www.mcca.tum.de ). [...]

Advanced breast cancer is associated with the development of brain metastases in 20%-40% of patients. Differential post-radiotherapy recurrence patterns depending on hormone receptor (HR) and human epidermal growth receptor 2 (HER2) status have been reported. [...]

Colorectal cancer (CRC) exhibits pronounced inter- and intratumoral heterogeneity, emphasizing the need for preclinical models that accurately capture its molecular and histological diversity. Patient-derived organoids (PDOs) represent valuable ex vivo systems to model CRC, yet whether they can preserve subtype-specific features and maintain fidelity upon in vivo transplantation remains unclear.We established a biobank of PDOs from both treatment-naïve and neoadjuvant-treated CRC patients, encompassing the major histological subtypes - micropapillary, medullary, serrated, mucinous, and adenocarcinoma not otherwise specified (NOS). [...]