TY  - JOUR
AU  - Mustafa, Shakhawan Abdulrahman
AU  - Pan, Longqiang
AU  - Marzoq, Aseel
AU  - Fawaz, Malak
AU  - Sander, Laureen Andrea
AU  - Rückert, Felix
AU  - Schrenk, Andrea
AU  - Hartl, Christina
AU  - Uhler, Rico
AU  - Yildirim, Adem
AU  - Strobel, Oliver
AU  - Hackert, Thilo
AU  - Giese, Nathalia
AU  - Büchler, Markus W
AU  - Hoheisel, Jörg
AU  - Alhamdani, Mohamed Saiel Saeed
TI  - Comparison of the tumor cell secretome and patient sera for an accurate serum-based diagnosis of pancreatic ductal adenocarcinoma.
JO  - OncoTarget
VL  - 8
IS  - 7
SN  - 1949-2553
CY  - [S.l.]
PB  - Impact Journals LLC
M1  - DKFZ-2017-00140
SP  - 11963-11976
PY  - 2017
N1  - 2017 Feb 14;8(7):11963-11976
AB  - Pancreatic cancer is the currently most lethal malignancy. Toward an accurate diagnosis of the disease in body liquids, we studied the protein composition of the secretomes of 16 primary and established cell lines of pancreatic ductal adenocarcinoma (PDAC). Compared to the secretome of non-tumorous cells, 112 proteins exhibited significantly different abundances. Functionally, the proteins were associated with PDAC features, such as decreased apoptosis, better cell survival and immune cell regulation. The result was compared to profiles obtained from 164 serum samples from two independent cohorts - a training and a test set - of patients with PDAC or chronic pancreatitis and healthy donors. Eight of the 112 secretome proteins exhibited similar variations in their abundance in the serum profile specific for PDAC patients, which was composed of altogether 189 proteins. The 8 markers shared by secretome and serum yielded a 95.1
LB  - PUB:(DE-HGF)16
C6  - pmid:28060763
DO  - DOI:10.18632/oncotarget.14449
UR  - https://inrepo02.dkfz.de/record/119386
ER  -