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@ARTICLE{Mustafa:119386,
      author       = {S. A. Mustafa$^*$ and L. Pan$^*$ and A. Marzoq$^*$ and M.
                      Fawaz$^*$ and L. A. Sander$^*$ and F. Rückert and A.
                      Schrenk and C. Hartl and R. Uhler and A. Yildirim$^*$ and O.
                      Strobel$^*$ and T. Hackert and N. Giese$^*$ and M. W.
                      Büchler and J. Hoheisel$^*$ and M. S. S. Alhamdani$^*$},
      title        = {{C}omparison of the tumor cell secretome and patient sera
                      for an accurate serum-based diagnosis of pancreatic ductal
                      adenocarcinoma.},
      journal      = {OncoTarget},
      volume       = {8},
      number       = {7},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-00140},
      pages        = {11963-11976},
      year         = {2017},
      note         = {2017 Feb 14;8(7):11963-11976},
      abstract     = {Pancreatic cancer is the currently most lethal malignancy.
                      Toward an accurate diagnosis of the disease in body liquids,
                      we studied the protein composition of the secretomes of 16
                      primary and established cell lines of pancreatic ductal
                      adenocarcinoma (PDAC). Compared to the secretome of
                      non-tumorous cells, 112 proteins exhibited significantly
                      different abundances. Functionally, the proteins were
                      associated with PDAC features, such as decreased apoptosis,
                      better cell survival and immune cell regulation. The result
                      was compared to profiles obtained from 164 serum samples
                      from two independent cohorts - a training and a test set -
                      of patients with PDAC or chronic pancreatitis and healthy
                      donors. Eight of the 112 secretome proteins exhibited
                      similar variations in their abundance in the serum profile
                      specific for PDAC patients, which was composed of altogether
                      189 proteins. The 8 markers shared by secretome and serum
                      yielded a $95.1\%$ accuracy of distinguishing PDAC from
                      healthy in a Receiver Operating Characteristic curve
                      analysis, while any number of serum-only markers produced
                      substantially less accurate results. Utility of the
                      identified markers was confirmed by classical enzyme linked
                      immunosorbent assays (ELISAs). The study highlights the
                      value of cell secretome analysis as a means of defining
                      reliable serum biomarkers.},
      cin          = {B070 / G180},
      ddc          = {610},
      cid          = {I:(DE-He78)B070-20160331 / I:(DE-He78)G180-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28060763},
      doi          = {10.18632/oncotarget.14449},
      url          = {https://inrepo02.dkfz.de/record/119386},
}