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024 7 _ |a 10.1038/ejcn.2013.235
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037 _ _ |a DKFZ-2017-00145
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Abbas, S.
|b 0
245 _ _ |a Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study.
260 _ _ |a New York, NY
|c 2014
|b Nature Publ. Group
336 7 _ |a article
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520 _ _ |a Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation.Using a case-cohort design, 11,245 incident cases of type 2 diabetes and a representative subcohort (N=15,798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires.Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend=0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D.This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.
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650 _ 7 |a Vitamin D
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700 1 _ |a Linseisen, J.
|b 1
700 1 _ |a Rohrmann, S.
|b 2
700 1 _ |a Beulens, J. W. J.
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700 1 _ |a Buijsse, B.
|b 4
700 1 _ |a Amiano, P.
|b 5
700 1 _ |a Ardanaz, E.
|b 6
700 1 _ |a Balkau, B.
|b 7
700 1 _ |a Boeing, H.
|b 8
700 1 _ |a Clavel-Chapelon, F.
|b 9
700 1 _ |a Fagherazzi, G.
|b 10
700 1 _ |a Franks, P. W.
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700 1 _ |a Gavrila, D.
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700 1 _ |a Grioni, S.
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700 1 _ |a Kaaks, R.
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700 1 _ |a Key, T. J.
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700 1 _ |a Khaw, K. T.
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700 1 _ |a Kühn, T.
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700 1 _ |a Mattiello, A.
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700 1 _ |a Molina-Montes, E.
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700 1 _ |a Nilsson, P. M.
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700 1 _ |a Overvad, K.
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700 1 _ |a Quirós, J. R.
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700 1 _ |a Rolandsson, O.
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700 1 _ |a Sacerdote, C.
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700 1 _ |a Saieva, C.
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700 1 _ |a Slimani, N.
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700 1 _ |a Sluijs, I.
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700 1 _ |a Spijkerman, A. M. W.
|b 28
700 1 _ |a Tjonneland, A.
|b 29
700 1 _ |a Tumino, R.
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700 1 _ |a van der A, D. L.
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700 1 _ |a Zamora-Ros, R.
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700 1 _ |a Sharp, S. J.
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700 1 _ |a Langenberg, C.
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700 1 _ |a Forouhi, N. G.
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700 1 _ |a Riboli, E.
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700 1 _ |a Wareham, N. J.
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773 _ _ |a 10.1038/ejcn.2013.235
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