Journal Article

DKFZ-2017-00145

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study.

Abbas, S. ; Linseisen, J. ; Rohrmann, S. ; Beulens, J. W. J. ; Buijsse, B. ; Amiano, P. ; Ardanaz, E. ; Balkau, B. ; Boeing, H. ; Clavel-Chapelon, F. ; Fagherazzi, G. ; Franks, P. W. ; Gavrila, D. ; Grioni, S. ; Kaaks, R.DKFZ* ; Key, T. J. ; Khaw, K. T. ; Kühn, T.DKFZ* ; Mattiello, A. ; Molina-Montes, E. ; Nilsson, P. M. ; Overvad, K. ; Quirós, J. R. ; Rolandsson, O. ; Sacerdote, C. ; Saieva, C. ; Slimani, N. ; Sluijs, I. ; Spijkerman, A. M. W. ; Tjonneland, A. ; Tumino, R. ; van der A, D. L. ; Zamora-Ros, R. ; Sharp, S. J. ; Langenberg, C. ; Forouhi, N. G. ; Riboli, E. ; Wareham, N. J.

2014
Nature Publ. Group New York, NY

This record in other databases:  

Please use a persistent id in citations: doi:10.1038/ejcn.2013.235

Abstract: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation.Using a case-cohort design, 11,245 incident cases of type 2 diabetes and a representative subcohort (N=15,798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires.Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend=0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D.This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

Keyword(s): Vitamin D

---

Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2014

---

Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---