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| Home > Publications database > Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients. > print |
| 001 | 119599 | ||
| 005 | 20240228134943.0 | ||
| 024 | 7 | _ | |a 10.18632/oncotarget.2385 |2 doi |
| 024 | 7 | _ | |a pmid:25230070 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4226673 |2 pmc |
| 024 | 7 | _ | |a altmetric:6426434 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-00231 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Baccelli, Irène |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients. |
| 260 | _ | _ | |a [S.l.] |c 2014 |b Impact Journals LLC |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1487937695_25476 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Although luminal-type primary breast cancer can be efficiently treated, development of metastatic disease remains a significant clinical problem. We have previously shown that luminal-type circulating tumor cells (CTCs) co-expressing the tyrosine-kinase MET and CD47, a ligand involved in cancer cell evasion from macrophage scavenging, are able to initiate metastasis in xenografts. Here, we investigated the clinical relevance of MET-CD47 co-expression in 255 hormone receptor positive breast tumors by immunohistochemistry and found a 10.3- year mean overall-survival difference between MET-CD47 double-positive and double-negative patients (p<0.001) MET-CD47 co-expression defined a novel independent prognosticator for overall-survival by multivariate analysis (Cox proportional hazards model: HR: 4.1, p<0.002) and CD47 expression alone or in combination with MET was strongly associated with lymph node metastasis. Furthermore, flow cytometric analysis of metastatic patient blood revealed consistent presence of MET+CD47+ CTCs (range 0.8 - 33.3% of CTCs) and their frequency was associated with increased metastatic spread. Finally, primary uncultured CTCs with high MET+CD47+ content showed an enhanced capacity to initiate metastasis in mice. Detection and targeting of MET and CD47 may thus provide a rational basis for risk stratification and treatment of patients with luminal-type breast cancer. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antigens, CD47 |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers, Tumor |2 NLM Chemicals |
| 650 | _ | 7 | |a CD47 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a MET protein, human |0 EC 2.7.10.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-met |0 EC 2.7.10.1 |2 NLM Chemicals |
| 700 | 1 | _ | |a Stenzinger, Albrecht |b 1 |
| 700 | 1 | _ | |a Vogel, Vanessa |0 P:(DE-He78)03fd0ab6ad061c771968971670c391e2 |b 2 |u dkfz |
| 700 | 1 | _ | |a Pfitzner, Berit Maria |b 3 |
| 700 | 1 | _ | |a Klein, Corinna |0 P:(DE-He78)0812f68beb25392984d3abbe3c58b6d2 |b 4 |u dkfz |
| 700 | 1 | _ | |a Wallwiener, Markus |b 5 |
| 700 | 1 | _ | |a Scharpff, Martina |b 6 |
| 700 | 1 | _ | |a Saini, Massimo |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 8 |u dkfz |
| 700 | 1 | _ | |a Sinn, Hans-Peter |b 9 |
| 700 | 1 | _ | |a Schneeweiss, Andreas |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Denkert, Carsten |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Weichert, Wilko |b 12 |
| 700 | 1 | _ | |a Trumpp, Andreas |0 P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2 |b 13 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.18632/oncotarget.2385 |g Vol. 5, no. 18, p. 8147 - 8160 |0 PERI:(DE-600)2560162-3 |n 18 |p 8147 - 8160 |t OncoTarget |v 5 |y 2014 |x 1949-2553 |
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| 914 | 1 | _ | |y 2014 |
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