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@ARTICLE{Northcott:120009,
      author       = {P. A. Northcott$^*$ and C. Lee and T. Zichner and A. M.
                      Stütz and S. Erkek$^*$ and D. Kawauchi$^*$ and D. J. H.
                      Shih and V. Hovestadt$^*$ and M. Zapatka$^*$ and D.
                      Sturm$^*$ and D. Jones$^*$ and M. Kool$^*$ and M. Remke and
                      F. M. G. Cavalli and S. Zuyderduyn and G. D. Bader and S.
                      VandenBerg and L. A. Esparza and M. Ryzhova and W. Wang$^*$
                      and A. Wittmann$^*$ and S. Stark$^*$ and L. Sieber$^*$ and
                      H. Seker-Cin$^*$ and L. Linke$^*$ and F. Kratochwil$^*$ and
                      N. Jäger$^*$ and I. Buchhalter$^*$ and C. D. Imbusch$^*$
                      and G. Zipprich$^*$ and B. Raeder and S. Schmidt$^*$ and N.
                      Diessl$^*$ and S. Wolf$^*$ and S. Wiemann$^*$ and B.
                      Brors$^*$ and C. Lawerenz$^*$ and J. Eils$^*$ and H.-J.
                      Warnatz and T. Risch and M.-L. Yaspo and U. Weber$^*$ and C.
                      C. Bartholomae$^*$ and C. von Kalle$^*$ and E. Turányi and
                      P. Hauser and E. Sanden and A. Darabi and P. Siesjö and J.
                      Sterba and K. Zitterbart and D. Sumerauer and P. van Sluis
                      and R. Versteeg and R. Volckmann and J. Koster and M. U.
                      Schuhmann and M. Ebinger and H. L. Grimes and G. W. Robinson
                      and A. Gajjar and M. Mynarek and K. von Hoff and S.
                      Rutkowski and T. Pietsch and W. Scheurlen and J. Felsberg
                      and G. Reifenberger and A. E. Kulozik and A. von
                      Deimling$^*$ and O. Witt$^*$ and R. Eils$^*$ and R. J.
                      Gilbertson and A. Korshunov$^*$ and M. D. Taylor and P.
                      Lichter$^*$ and J. O. Korbel$^*$ and R. J. Wechsler-Reya$^*$
                      and S. Pfister$^*$},
      title        = {{E}nhancer hijacking activates {GFI}1 family oncogenes in
                      medulloblastoma.},
      journal      = {Nature},
      volume       = {511},
      number       = {7510},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group52462},
      reportid     = {DKFZ-2017-00597},
      pages        = {428 - 434},
      year         = {2014},
      abstract     = {Medulloblastoma is a highly malignant paediatric brain
                      tumour currently treated with a combination of surgery,
                      radiation and chemotherapy, posing a considerable burden of
                      toxicity to the developing child. Genomics has illuminated
                      the extensive intertumoral heterogeneity of medulloblastoma,
                      identifying four distinct molecular subgroups. Group 3 and
                      group 4 subgroup medulloblastomas account for most
                      paediatric cases; yet, oncogenic drivers for these subtypes
                      remain largely unidentified. Here we describe a series of
                      prevalent, highly disparate genomic structural variants,
                      restricted to groups 3 and 4, resulting in specific and
                      mutually exclusive activation of the growth factor
                      independent 1 family proto-oncogenes, GFI1 and GFI1B.
                      Somatic structural variants juxtapose GFI1 or GFI1B coding
                      sequences proximal to active enhancer elements, including
                      super-enhancers, instigating oncogenic activity. Our
                      results, supported by evidence from mouse models, identify
                      GFI1 and GFI1B as prominent medulloblastoma oncogenes and
                      implicate enhancer hijacking as an efficient mechanism
                      driving oncogene activation in a childhood cancer.},
      keywords     = {DNA-Binding Proteins (NLM Chemicals) / GFI1 protein, human
                      (NLM Chemicals) / GFI1B protein, human (NLM Chemicals) /
                      Proto-Oncogene Proteins (NLM Chemicals) / Repressor Proteins
                      (NLM Chemicals) / Transcription Factors (NLM Chemicals)},
      cin          = {B062 / B060 / B080 / W190 / G100 / B050 / G380 / G340 /
                      G200},
      ddc          = {070},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)W190-20160331 /
                      I:(DE-He78)G100-20160331 / I:(DE-He78)B050-20160331 /
                      I:(DE-He78)G380-20160331 / I:(DE-He78)G340-20160331 /
                      I:(DE-He78)G200-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25043047},
      pmc          = {pmc:PMC4201514},
      doi          = {10.1038/nature13379},
      url          = {https://inrepo02.dkfz.de/record/120009},
}