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| Home > Publications database > Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. |
| Home > Publications database > Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. |
| Journal Article | DKFZ-2017-00597 |
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2014
Nature Publ. Group52462
London [u.a.]
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Please use a persistent id in citations: doi:10.1038/nature13379
Abstract: Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate enhancer hijacking as an efficient mechanism driving oncogene activation in a childhood cancer.
Keyword(s): DNA-Binding Proteins ; GFI1 protein, human ; GFI1B protein, human ; Proto-Oncogene Proteins ; Repressor Proteins ; Transcription Factors
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