TY  - JOUR
AU  - Oakes, Christopher C
AU  - Claus, Rainer
AU  - Gu, Lei
AU  - Assenov, Yassen
AU  - Hüllein, Jennifer
AU  - Zucknick, Manuela
AU  - Bieg, Matthias
AU  - Brocks, David
AU  - Bogatyrova, Olga
AU  - Schmidt, Christopher R
AU  - Rassenti, Laura
AU  - Kipps, Thomas J
AU  - Mertens, Daniel
AU  - Lichter, Peter
AU  - Döhner, Hartmut
AU  - Stilgenbauer, Stephan
AU  - Byrd, John C
AU  - Zenz, Thorsten
AU  - Plass, Christoph
TI  - Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.
JO  - Cancer discovery
VL  - 4
IS  - 3
SN  - 2159-8290
CY  - Philadelphia, Pa.
M1  - DKFZ-2017-00611
SP  - 348 - 361
PY  - 2014
AB  - Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation heterogeneity and up to 10
LB  - PUB:(DE-HGF)16
C6  - pmid:24356097
C2  - pmc:PMC4134522
DO  - DOI:10.1158/2159-8290.CD-13-0349
UR  - https://inrepo02.dkfz.de/record/120023
ER  -