Journal Article

DKFZ-2017-00611

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.

Oakes, C. C. (First author)DKFZ* ; Claus, R.DKFZ* ; Gu, L.DKFZ* ; Assenov, Y.DKFZ* ; Hüllein, J.DKFZ* ; Zucknick, M.DKFZ* ; Bieg, M.DKFZ* ; Brocks, D.DKFZ* ; Bogatyrova, O.DKFZ* ; Schmidt, C. R.DKFZ* ; Rassenti, L. ; Kipps, T. J. ; Mertens, D.DKFZ* ; Lichter, P.DKFZ* ; Döhner, H. ; Stilgenbauer, S. ; Byrd, J. C. ; Zenz, T.DKFZ* ; Plass, C. (Last author)DKFZ*

2014
Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/2159-8290.CD-13-0349

Abstract: Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing to evaluate intratumor heterogeneity and evolution of DNA methylation and genetic aberrations in chronic lymphocytic leukemia (CLL). CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation heterogeneity and up to 10% of total CpGs in a monoallelically methylated state. Increasing methylation heterogeneity correlates with advanced genetic subclonal complexity. Selection of novel DNA methylation patterns is observed only in cases that undergo genetic evolution, and independent genetic evolution is uncommon and is restricted to low-risk alterations. These results reveal that although evolution of DNA methylation occurs in high-risk, clinically progressive cases, positive selection of novel methylation patterns entails coevolution of genetic alteration(s) in CLL.

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Contributing Institute(s):

1. Epigenomik und Krebsrisikofaktoren (C010)
2. Theoretische Bioinformatik (B080)
3. Biostatistik (C060)
4. Molekulare Genetik (B060)
5. Translationale Onkologie (G100)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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