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@ARTICLE{Oakes:120023,
      author       = {C. C. Oakes$^*$ and R. Claus$^*$ and L. Gu$^*$ and Y.
                      Assenov$^*$ and J. Hüllein$^*$ and M. Zucknick$^*$ and M.
                      Bieg$^*$ and D. Brocks$^*$ and O. Bogatyrova$^*$ and C. R.
                      Schmidt$^*$ and L. Rassenti and T. J. Kipps and D.
                      Mertens$^*$ and P. Lichter$^*$ and H. Döhner and S.
                      Stilgenbauer and J. C. Byrd and T. Zenz$^*$ and C.
                      Plass$^*$},
      title        = {{E}volution of {DNA} methylation is linked to genetic
                      aberrations in chronic lymphocytic leukemia.},
      journal      = {Cancer discovery},
      volume       = {4},
      number       = {3},
      issn         = {2159-8290},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2017-00611},
      pages        = {348 - 361},
      year         = {2014},
      abstract     = {Although clonal selection by genetic driver aberrations in
                      cancer is well documented, the ability of epigenetic
                      alterations to promote tumor evolution is undefined. We used
                      450k arrays and next-generation sequencing to evaluate
                      intratumor heterogeneity and evolution of DNA methylation
                      and genetic aberrations in chronic lymphocytic leukemia
                      (CLL). CLL cases exhibit vast interpatient differences in
                      intratumor methylation heterogeneity, with genetically
                      clonal cases maintaining low methylation heterogeneity and
                      up to $10\%$ of total CpGs in a monoallelically methylated
                      state. Increasing methylation heterogeneity correlates with
                      advanced genetic subclonal complexity. Selection of novel
                      DNA methylation patterns is observed only in cases that
                      undergo genetic evolution, and independent genetic evolution
                      is uncommon and is restricted to low-risk alterations. These
                      results reveal that although evolution of DNA methylation
                      occurs in high-risk, clinically progressive cases, positive
                      selection of novel methylation patterns entails coevolution
                      of genetic alteration(s) in CLL.},
      cin          = {C010 / B080 / C060 / B060 / G100},
      ddc          = {610},
      cid          = {I:(DE-He78)C010-20160331 / I:(DE-He78)B080-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)G100-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24356097},
      pmc          = {pmc:PMC4134522},
      doi          = {10.1158/2159-8290.CD-13-0349},
      url          = {https://inrepo02.dkfz.de/record/120023},
}